ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019
Controlled induction and targeted elimination of p16
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 57 citations in OpenAlex.
- Dasatinib and quercetin senolytic treatment delays early onset intervertebral disc degeneration in SM/J mice.Bone research · 2026Article
- Explant Culture for Studying Lung Development.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Dasatinib and quercetin senolytic treatment delays early onset intervertebral disc degeneration in SM/J mice.Research square · 2025Article
- Transcriptomic analysis of skeletal muscle regeneration across mouse lifespan identifies altered stem cell states.Nature aging · 2024Article
- Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes.Aging · 2023Article
- Application of human platelet lysate in chondrocyte expansion promotes chondrogenic phenotype and slows senescence progression via BMP-TAK1-p38 pathway.Scientific reports · 2023Article
- Article
- Conversion of senescent cartilage into a pro-chondrogenic microenvironment with antibody-functionalized copper sulfate nanoparticles for efficient osteoarthritis therapy.Journal of nanobiotechnology · 2023Article
- Inhibition of tyrosine kinase Fgr prevents radiation-induced pulmonary fibrosis (RIPF).Cell death discovery · 2023Article
- Research and publication trends on knee osteoarthritis and cellular senescence: a bibliometric analysis.Frontiers in physiology · 2023Article
- Senescence-accelerated mice prone 8 (SAMP8) in male as a spontaneous osteoarthritis model.Arthritis research & therapy · 2022Article
- The cGAS-STING Pathway Affects Vertebral Bone but Does Not Promote Intervertebral Disc Cell Senescence or Degeneration.Frontiers in immunology · 2022Article
- Senomorphic agent pterostilbene ameliorates osteoarthritis through the PI3K/AKT/NF-κB axis: an in vitro and in vivo study.American journal of translational research · 2022Article
- Ionizing irradiation-induced Fgr in senescent cells mediates fibrosis.Cell death discovery · 2021Article
- Cellular senescence in musculoskeletal homeostasis, diseases, and regeneration.Bone research · 2021Review
- Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice.Nature communications · 2021Article
- Radiation-Induced Senescence in p16+/LUC Mouse Lung Compared to Bone Marrow Multilineage Hematopoietic Progenitor Cells.Radiation research · 2021Article
- [Research progress of cellular senescence in the pathogenesis of osteoarthritis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2021Review
- The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence.Osteoarthritis and cartilage · 2021Article
- Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Cellular senescence is a phenotypic state that contributes to age-related diseases through the secretion of matrix-degrading and inflammatory molecules. An emerging therapeutic strategy for osteoarthritis (OA) is to selectively eliminate senescent cells by initiating apoptosis. This study establishes a cartilage explant model of senescence induction and senolytic clearance using
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.