Evidence map›Paper›PMID 31408325›Full record

ArticleBiomacromolecules2019

Alkyne-Tagged PLGA Allows Direct Visualization of Nanoparticles In Vitro and Ex Vivo by Stimulated Raman Scattering Microscopy.

Sally Vanden-Hehir, Stefan A Cairns, Martin Lee, Lida Zoupi, Michael P Shaver, Valerie G Brunton, Anna Williams, Alison N Hulme

Open access · hybridAbstract read
In one paragraph

Article in Biomacromolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

  1. Raman imaging of molecular groups in the wavenumber silent region.Analytical and bioanalytical chemistry · 2026
    Review
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  5. Article
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  7. Review
  8. Single-particle imaging of nanomedicine entering the brain.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Perspectives on SRS Imaging of Nanoparticles.Accounts of materials research · 2023
    Article
  10. Review
  11. Review
  12. Raman Spectroscopy as a Tool to Study the Pathophysiology of Brain Diseases.International journal of molecular sciences · 2023
    Review
  13. Review
  14. Review
  15. Advances in stimulated Raman scattering imaging for tissues and animals.Quantitative imaging in medicine and surgery · 2021
    Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sally Vanden-HehirEaStCHEM School of Chemistry , University of Edinburgh , David Brewster Road , Edinburgh , EH9 3FJ , United Kingdom.
Stefan A CairnsEaStCHEM School of Chemistry , University of Edinburgh , David Brewster Road , Edinburgh , EH9 3FJ , United Kingdom.
Martin LeeEdinburgh Cancer Research UK Centre , University of Edinburgh, Western General Hospital , Crewe Road South , Edinburgh , EH4 2XR , United Kingdom.
Lida ZoupiMRC Centre for Regenerative Medicine , The University of Edinburgh , Edinburgh BioQuarter, 5, Little France Drive , Edinburgh , EH16 4UU , United Kingdom.
Michael P ShaverEaStCHEM School of Chemistry , University of Edinburgh , David Brewster Road , Edinburgh , EH9 3FJ , United Kingdom.ORCID 0000-0002-7152-6750
Valerie G BruntonEdinburgh Cancer Research UK Centre , University of Edinburgh, Western General Hospital , Crewe Road South , Edinburgh , EH4 2XR , United Kingdom.
Anna WilliamsMRC Centre for Regenerative Medicine , The University of Edinburgh , Edinburgh BioQuarter, 5, Little France Drive , Edinburgh , EH16 4UU , United Kingdom.
Alison N HulmeEaStCHEM School of Chemistry , University of Edinburgh , David Brewster Road , Edinburgh , EH9 3FJ , United Kingdom.ORCID 0000-0002-4619-1506
University of Edinburgh · GBMRC Centre for Regenerative Medicine · GBWestern General Hospital · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M010996/1Cancer Research UK 15703Cancer Research UK C157/A15703Cancer Research UK C157/A25140Chief Scientist Office CGA/18/20Medical Research Council MR/K017047/1Medical Research Council MR/K026666/1Medical Research Council MR/P016022/1Medical Research Council MR/S035915/1
6 · The paper itself

Abstract

Polymeric nanoparticles (NPs) are attractive candidates for the controlled and targeted delivery of therapeutics in vitro and in vivo. However, detailed understanding of the uptake, location, and ultimate cellular fate of the NPs is necessary to satisfy safety concerns, which is difficult because of the nanoscale size of these carriers. In this work, we show how small chemical labels can be appended to poly(lactic acid-

Indexed as

AlkynesAnimalsDrug CarriersDrug Delivery SystemsMiceMice, Inbred C57BLMicrogliaNanoparticlesNonlinear Optical MicroscopyPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerRatsAlkynesDrug CarriersPolyglycolic AcidPolylactic Acid-Polyglycolic Acid Copolymer

Identifiers

PMID31408325
PMCPMC6794644
OpenAlexW2968950940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.