ReviewAddiction (Abingdon, England)2020
Heavy cannabis use, dependence and the brain: a clinical perspective.
Review in Addiction (Abingdon, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed.
- EEG-based network dynamics in cannabis and polydrug use: a directed transfer function approach.Psychopharmacology · 2026Article
- Attitudes toward tobacco-free and cannabis-free policies among residents in permanent supportive housing who use tobacco, cannabis, and other substances.Addictive behaviors reports · 2026Article
- Operationalizing ASSIST-based indicators to estimate the prevalence and correlates of problematic cannabis involvement among U.S. college students.Journal of cannabis research · 2026Article
- Social cognition in young adults who endorse a cannabis use disorder.Psychopharmacology · 2026Article
- The Paradoxical Effect of Cannabis Use on Cognition in Chronic Psychotic Disorders.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Article
- Motion and form perception in healthy individuals with adolescent cannabis use.Frontiers in psychiatry · 2026Article
- A computational mechanism linking momentary craving and decision-making in alcohol drinkers and cannabis users.Nature. Mental health · 2026Article
- The effectiveness of psychological interventions delivered by health professionals for adult cannabis use in community settings: a systematic review and meta-analysis.Frontiers in psychiatry · 2026Review
- Emotional interference and right prefrontal hemodynamic responses in adult cannabis users: a pilot fNIRS study.Frontiers in psychology · 2026Article
- Cannabis use frequency may differentially impact cognitive performance in young adults with and without HIV.Frontiers in adolescent medicine · 2026Article
- History of cannabis use and cognitive function in older adults: findings from the UK biobank.Age and ageing · 2025Article
- Demographic, economic, and social status and knowledge of medical and alternative cannabis use among Northeastern Thai citizens: a case study of outpatients at community hospitals along the Thai-Cambodian border.Journal of cannabis research · 2025Article
- Cannabis use and cognition in older adults: Preliminary performance-based neuropsychological test results and directions for future research.Journal of the International Neuropsychological Society : JINS · 2025Observational
- Cognitive Effects of Cannabis Use: A Comprehensive Review Across Domains.Neurology international · 2025Review
- Daily Cannabis Use: Do Impulsivity and Sensation Seeking Predict Negative Cannabis Related Consequences?Journal of drug issues · 2025Article
- Patient-provider interactions about cannabis for therapeutic purposes vary as a function of provider type: A pilot study.The American journal on addictions · 2025Article
- The safety and efficacy of cannabinoids for the treatment of mental health and substance use disorders: protocol for a systematic review and meta-analysis.Systematic reviews · 2025Article
- Emerging trends in cannabis administration for women with chronic pain.Mental health science · 2024Article
- Sex Differences in the Association Between Cumulative Use of Cannabis and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults Study.Cannabis and cannabinoid research · 2024Article
- Heavy Lifetime Cannabis Use and Mortality by Sex.JAMA network open · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
aimsTo summarize and evaluate our knowledge of the relationship between heavy cannabis use, cannabis use disorder (CUD) and the brain.
methodsNarrative review of relevant literature identified through existing systematic reviews, meta-analyses and a PubMed search. Epidemiology, clinical representations, potential causal mechanisms, assessments, treatment and prognosis are discussed.
resultsAlthough causality is unclear, heavy and dependent cannabis use is consistently associated with a high prevalence of comorbid psychiatric disorders and learning and memory impairments that seem to recover after a period of abstinence. Evidence regarding other cognitive domains and neurological consequences, including cerebrovascular events, is limited and inconsistent. Abstinence after treatment is only achieved in a minority of cases; treatment targeted at reduction in use appears have some success. Potential moderators of the impact of CUD on the brain include age of onset, heaviness of use, CUD severity, the ratio of ∆9-tetrahydrocannabinol to cannabidiol and severity of comorbid disorders.
conclusionsCurrent evidence of long-term effects of daily cannabis use and cannabis use disorder on brain-related outcomes is suggestive rather than conclusive, but use is associated with psychiatric morbidity and with cognitive impairments that recover after a period of abstinence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.