Evidence map›Paper›PMID 31408149›Full record

ArticleThe Journal of clinical endocrinology and metabolism2019

Testosterone and Estrone Increase From the Age of 70 Years: Findings From the Sex Hormones in Older Women Study.

Susan R Davis, Robin J Bell, Penelope J Robinson, David J Handelsman, Tom Gilbert, James Phung, Reena Desai, Jessica E Lockery, Robyn L Woods, Rory S Wolfe and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Observational
  13. Review
  14. Article
  15. Observational
  16. Article
  17. Sex hormones, SHBG and cognitive performance among older Australian women: an observational study.Climacteric : the journal of the International Menopause Society · 2023
    Observational
  18. Estrone, sex hormone binding globulin and lipid profiles in older women: an observational study.Climacteric : the journal of the International Menopause Society · 2023
    Observational
  19. Concentrations of endogenous sex steroid hormones and SHBG in healthy postmenopausal women.The Journal of steroid biochemistry and molecular biology · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Susan R DavisWomen's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria Australia.
Robin J BellWomen's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria Australia.
Penelope J RobinsonWomen's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria Australia.
David J HandelsmanANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia.
Tom GilbertDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
James PhungDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Reena DesaiANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia.
Jessica E LockeryDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Robyn L WoodsDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Rory S WolfeDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Christopher M ReidSchool of Public Health, Curtin University, Perth, Western Australia, Australia.
Mark R NelsonDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Anne M MurrayBerman Center for Outcomes and Clinical Research, Hennepin Healthcare Research Institute, Hennepin Healthcare, Minneapolis, Minnesota.
John J McNeilDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
ASPREE Investigator Group
Monash University · AUThe University of Sydney · AUCurtin University · AUUniversity of Minnesota · USUniversity of Tasmania · AU

Funding

ASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6M
Main Administrative CoreU19AG062682 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI CHAN, ANDREW T, MCNEIL, JOHN JAMES · 2019 to 2023
$42.9M
NIA NIH HHS U01 AG029824NIA NIH HHS U19 AG062682
6 · The paper itself

Abstract

contextThere is a lack of understanding of what is normal in terms of sex steroid levels in older women.

objectiveTo determine whether sex steroid levels vary with age in and establish reference ranges for women >70 years of age. DESIGN AND

settingCross-sectional, community-based study.

participantsIncluded 6392 women ≥70 years of age.

main outcome measuresSex steroids measured by liquid chromatography-tandem mass spectrometry. A reference group, to establish sex steroid age-specific reference ranges, excluded women using systemic or topical sex steroid, antiandrogen or glucocorticoid therapy, or an antiglycemic agent.

resultsThe reference group of 5326 women had a mean age of 75.1 (±4.2) years, range of 70 to 94.7 years. Median values (range) were 181.2 pmol/L (3.7 to 5768.9) for estrone (E1), 0.38 nmol/L (0.035 to 8.56) for testosterone (T), 2.60 nmol/L (0.07 to 46.85) for dehydroepiandrosterone (DHEA), and 41.6 nmol/L (2.4 to 176.6) for SHBG. Estradiol and DHT were below method sensitivity in 66.1% and 72.7% of the samples, respectively. Compared with women aged 70 to 74 years, women aged ≥85 years had higher median levels of E1 (11.7%, P = 0.01), T (11.3%, P = 0.02), and SHBG (22.7%, P < 0.001) and lower DHEA (30% less, P < 0.001). Women with overweight and obesity had higher E1 (P < 0.001) and T (P < 0.03) and lower SHBG (P < 0.001) than did women with normal body mass index. Smokers had 17.2% higher median T levels (P = 0.005).

conclusionFrom the age of 70 years, T and E1 increase with age, despite a steady decline in DHEA. Whether E1 and T are biomarkers for longevity or contribute to healthy aging merits investigation.

Indexed as

AgingAgedAged, 80 and overBiomarkersCommunity-Based Participatory ResearchCross-Sectional StudiesDehydroepiandrosteroneEstroneFemaleFollow-Up StudiesHumansObesityOverweightPrognosisTestosteroneBiomarkersDehydroepiandrosteroneEstroneTestosterone

Identifiers

PMID31408149
PMCPMC6830527
OpenAlexW2967109423

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.