ArticlePain2019
Whole-brain functional network disruption in chronic pain with disk herniation.
Article in Pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Connectomic Mapping of Chronic Musculoskeletal Pain: Neural Circuitries Identified Through a Systematic Review and ALE Meta-Analysis.Neural plasticity · 2026Pooled it
- Brain functional changes following spinal manipulation therapy in patients with lumbar disc herniation and chronic low back pain: a scoping review.Frontiers in neurology · 2025Pooled it
- Brain network properties in chronic pain-a systematic review and meta-analysis of graph-based connectivity metrics.Frontiers in neuroscience · 2025Pooled it
- Tuina Alleviates Pain Associated with Lumbar Disc Herniation by Regulating Functional Connectivity Between Inferior Frontal Triangularis and Multiple Brain Networks: A Randomized Controlled fMRI Study.Journal of pain research · 2026Trial
- Immersive virtual reality-based rehabilitation for subacute stroke: a randomized controlled trial.Journal of neurology · 2024Trial
- Trial
- Optimizing Chronic Pain Treatment with Enhanced Neuroplastic Responsiveness: A Pilot Randomized Controlled Trial.Nutrients · 2021Trial
- From localized to long-range: functional connectivity alterations in mild to moderate chronic low back pain patients.Quantitative imaging in medicine and surgery · 2026Article
- Transcriptional signatures of aberrant brain functional network topology in chronic low back pain with lumbar disc herniation.Frontiers in molecular neuroscience · 2026Article
- Central and peripheral factors moderating pain effects on motor control and disability in chronic lumbosacral radicular pain.Journal of neuroengineering and rehabilitation · 2025Article
- Mechanistic and Clinical Evaluation of Lever-Positioning Manipulation in Lumbar Disc Herniation: A Study Protocol for a Randomized Controlled Trial Using Rs-fMRI.Journal of pain research · 2025Article
- Body mass index associated with respiration predicts motion in resting-state functional magnetic resonance imaging scans.Human brain mapping · 2024Article
- Graph Metrics Reveal Brain Network Topological Property in Neuropathic Pain Patients: A Systematic Review.Journal of pain research · 2024Review
- Degree centrality-based resting-state functional magnetic resonance imaging explores central mechanisms in lumbar disc herniation patients with chronic low back pain.Frontiers in neurology · 2024Article
- Research on the multidimensional brain remodeling mechanisms at the level of brain regions, circuits, and networks in patients with chronic lower back pain caused by lumbar disk herniation.Frontiers in neuroscience · 2024Article
- Pain sensitivity and quality of life of patients with burning mouth syndrome: a preliminary study in a Chinese population.BMC oral health · 2023Article
- Clinical Characteristics of Minimal Lumbar Disc Herniation and Efficacy of Percutaneous Endoscopic Lumbar Discectomy via Transforaminal Approach: A Retrospective Study.Journal of personalized medicine · 2023Article
- Traditional Chinese Manual Therapy (Tuina) reshape the function of default mode network in patients with lumbar disc herniation.Frontiers in neuroscience · 2023Article
- Brain Connectivity Predicts Chronic Pain in Acute Mild Traumatic Brain Injury.Annals of neurology · 2022Article
- Brain Morphological and Functional Changes in Adenomyosis with Pain: A Resting State Functional Magnetic Resonance Imaging Study.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Brain functional network properties are globally disrupted in multiple musculoskeletal chronic pain conditions. Back pain with lumbar disk herniation (LDH) is highly prevalent and a major route for progression to chronic back pain. However, brain functional network properties remain unknown in such patients. Here, we examined resting-state functional magnetic resonance imaging-based functional connectivity networks in chronic back pain patients with clear evidence for LDH (LDH-chronic pain n = 146), in comparison to healthy controls (HCs, n = 165). The study was conducted in China, thus providing the opportunity to also examine the influence of culture on brain functional reorganization with chronic pain. The data were equally subdivided into discovery and validation subgroups (n = 68 LDH-chronic pain and n = 68 HC, for each subgroup), and contrasted to an off-site data set (n = 272, NITRC 1000). Graph disruption indices derived from 3 network topological measurements, degree, clustering coefficient, and efficiency, which respectively represent network hubness, segregation, and integration, were significantly decreased compared with HC, across all predefined link densities, in both discovery and validation groups. However, global mean clustering coefficient and betweenness centrality were decreased in the discovery group and showed trend in the validation group. The relationship between pain and graph disruption indices was limited to males with high education. These results deviate somewhat from recent similar analysis for other musculoskeletal chronic pain conditions, yet we cannot determine whether the differences are due to types of pain or also to cultural differences between patients studied in China and the United States.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.