ReviewAnnals of the New York Academy of Sciences2020
Between persistently active and activity-silent frameworks: novel vistas on the cellular basis of working memory.
Review in Annals of the New York Academy of Sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Differential roles of frontoparietal regions in working memory and decision-making.bioRxiv : the preprint server for biology · 2026Article
- Effects of sleep quality on the offline storage state of visual working memory.BMC psychology · 2026Article
- History bias and its perturbation of the stimulus representation in the macaque prefrontal cortex.The Journal of physiology · 2026Article
- Selective recognition memory impairment in mitochondrial hydroxylase Clk1 mutant mice, rescued by antipsychotics.Acta pharmacologica Sinica · 2026Article
- Unattended working memory items are coded by persistent activity in human medial temporal lobe neurons.Nature human behaviour · 2025Article
- Persistent activity during working memory maintenance predicts long-term memory formation in the human hippocampus.Neuron · 2024Article
- High frequency oscillations in human memory and cognition: a neurophysiological substrate of engrams?Brain : a journal of neurology · 2024Review
- Working memory expedites the processing of visual signals within the extrastriate cortex.iScience · 2024Article
- Persistent activity during working memory maintenance predicts long-term memory formation in the human hippocampus.bioRxiv : the preprint server for biology · 2024Article
- Article
- Theta-Alpha Connectivity in the Hippocampal-Entorhinal Circuit Predicts Working Memory Load.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The Relation Between Attention and Memory.Annual review of psychology · 2024Review
- Dataset of human-single neuron activity during a Sternberg working memory task.Scientific data · 2024Article
- Concurrent maintenance of both veridical and transformed working memory representations within unique coding schemes.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- No evidence that visual impulses enhance the readout of retrieved long-term memory contents from EEG activity.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Spatial Configuration Effects on the Dissociation between Active and Latent States in Visual Working Memory.Behavioral sciences (Basel, Switzerland) · 2023Article
- Differential effects of executive load on automatic versus controlled semantic memory retrieval.Memory & cognition · 2023Article
- A unifying perspective on neural manifolds and circuits for cognition.Nature reviews. Neuroscience · 2023Review
- Distinct hippocampal-prefrontal neural assemblies coordinate memory encoding, maintenance, and recall.Current biology : CB · 2023Article
- Article
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Authors and funding
2 authors.
Funding
Abstract
Recent work has revealed important new discoveries on the cellular mechanisms of working memory (WM). These findings have motivated several seemingly conflicting theories on the mechanisms of short-term memory maintenance. Here, we summarize the key insights gained from these new experiments and critically evaluate them in light of three hypotheses: classical persistent activity, activity-silent, and dynamic coding. The experiments discussed include the first direct demonstration of persistently active neurons in the human medial temporal lobe that form static attractors with relevance to WM, single-neuron recordings in the macaque prefrontal cortex that show evidence for both persistent and more dynamic types of WM representations, and noninvasive neuroimaging in humans that argues for activity-silent representations. A key insight that emerges from these new results is that there are several neural mechanisms that support the maintenance of information in WM. Finally, based on established cognitive theories of WM, we propose a coherent model that encompasses these seemingly contradictory results. We propose that the three neuronal mechanisms of persistent activity, activity-silent, and dynamic coding map well onto the cognitive levels of information processing (within focus of attention, activated long-term memory, and central executive) that Cowan's WM model proposes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.