Evidence map›Paper›PMID 31407662›Full record

ArticleeLife2019

Somatosensory neurons integrate the geometry of skin deformation and mechanotransduction channels to shape touch sensing.

Alessandro Sanzeni, Samata Katta, Bryan Petzold, Beth L Pruitt, Miriam B Goodman, Massimo Vergassola

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Correction.Current topics in behavioral neurosciences · 2025
    Article
  3. Review
  4. Article
  5. The influence of internal pressure and neuromuscular agents onFrontiers in bioengineering and biotechnology · 2024
    Article
  6. Article
  7. Article
  8. Reciprocal interactions between transforming growth factor beta signaling and collagens: Insights from Caenorhabditis elegans.Developmental dynamics : an official publication of the American Association of Anatomists · 2022
    Article
  9. Article
  10. The Rheology of the Carotid Sinus: A Path Toward Bioinspired Intervention.Frontiers in bioengineering and biotechnology · 2021
    Review
  11. Article
  12. A quantal code for touch intensity inThe Journal of general physiology · 2019
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Alessandro SanzeniDepartment of Physics, University of California, San Diego, La Jolla, United States.ORCID 0000-0001-8758-1810
Samata KattaNeuroscience Program, Stanford University School of Medicine, Stanford, United States.ORCID 0000-0001-9748-1653
Bryan PetzoldDepartment of Mechanical Engineering, Stanford University, Stanford, United States.
Beth L PruittDepartment of Mechanical Engineering, Stanford University, Stanford, United States.ORCID 0000-0002-4861-2124
Miriam B GoodmanDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States.ORCID 0000-0002-5810-1272
Massimo VergassolaDepartment of Physics, University of California, San Diego, La Jolla, United States.ORCID 0000-0002-7212-8244
Stanford University · USNational Institutes of Health · USUniversity of California San Diego · US

Funding

The biophysics of skin-neuron sensory tactile organs and their sensitivity to mechanical and chemical stressR35NS105092 · NINDS · STANFORD UNIVERSITY · PI GOODMAN, MIRIAM B · 2018 to 2025
$6.4M
Molecular Basis of Sensory Transduction in C. elegansR01NS047715 · NINDS · STANFORD UNIVERSITY · PI GOODMAN, MIRIAM B · 2004 to 2017
$4.9M
Force Clamp Systems for Evaluation of MechanotransductionR01EB006745 · NIBIB · STANFORD UNIVERSITY · PI GOODMAN, MIRIAM B, PRUITT, BETH L · 2007 to 2014
$3.1M
Determinants of Mechanotransduction SensitivityF31NS093825 · NINDS · STANFORD UNIVERSITY · PI KATTA, SAMATA · 2015 to 2016
$69k
NIH HHS F31-NS-093825NIH HHS R01-EB-006745NIH HHS R01-NS-047715NIH HHS R35-NS-105092
6 · The paper itself

Abstract

Touch sensation hinges on force transfer across the skin and activation of mechanosensitive ion channels along the somatosensory neurons that invade the skin. This skin-nerve sensory system demands a quantitative model that spans the application of mechanical loads to channel activation. Unlike prior models of the dynamic responses of touch receptor neurons in

Indexed as

Skin Physiological PhenomenaStress, MechanicalTouchAnimalsCaenorhabditis elegansMechanoreceptorsModels, NeurologicalSensory Receptor CellsSkinC. elegansphysics of living systemssomatosensory neurons responsetissue mechanicstouch sensation

Identifiers

PMID31407662
PMCPMC6692131
OpenAlexW2968446592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.