ArticleAnnals of clinical and translational neurology2019
Probing axons using multi-compartmental diffusion in multiple sclerosis.
Article in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Intracellular fluid accumulation underlies brain volume increases in early Alzheimer's disease.Brain communications · 2026Article
- Updates in Multiple Sclerosis Imaging.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2025Review
- Microscopic fractional anisotropy outperforms multiple sclerosis lesion assessment and clinical outcome associations over standard fractional anisotropy tensor.Human brain mapping · 2024Article
- Watershed regions are more susceptible to tissue microstructural injury in multiple sclerosis.Brain communications · 2024Article
- Central vein sign and diffusion MRI differentiate microstructural features within white matter lesions of multiple sclerosis patients with comorbidities.Frontiers in neurology · 2023Article
- Correlations between hippocampal functional connectivity, structural changes, and clinical data in patients with relapsing-remitting multiple sclerosis: a case-control study using multimodal magnetic resonance imaging.Neural regeneration research · 2022Article
- White matter tracts that overlap with the thalamus and the putamen are protected against multiple sclerosis pathology.Multiple sclerosis and related disorders · 2022Article
- Transcallosal and Corticospinal White Matter Disease and Its Association With Motor Impairment in Multiple Sclerosis.Frontiers in neurology · 2022Article
- On the potential for mapping apparent neural soma density via a clinically viable diffusion MRI protocol.NeuroImage · 2021Article
- Assessing brain injury topographically using MR neurite orientation dispersion and density imaging in multiple sclerosis.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021Article
- Perilesional neurodegenerative injury in multiple sclerosis: Relation to focal lesions and impact on disability.Multiple sclerosis and related disorders · 2021Article
- Comparison of Neurite Orientation Dispersion and Density Imaging and Two-Compartment Spherical Mean Technique Parameter Maps in Multiple Sclerosis.Frontiers in neurology · 2021Article
- Challenges for biophysical modeling of microstructure.Journal of neuroscience methods · 2020Review
- Advanced Multicompartment Diffusion MRI Models and Their Application in Multiple Sclerosis.AJNR. American journal of neuroradiology · 2020Review
- Characterization of multiple sclerosis lesions with distinct clinical correlates through quantitative diffusion MRI.NeuroImage. Clinical · 2020Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
Abstract
objectsThe diffusion-based spherical mean technique (SMT) provides a novel model to relate multi-b-value diffusion magnetic resonance imaging (MRI) data to features of tissue microstructure. We propose the first clinical application of SMT to image the brain of patients with multiple sclerosis (MS) and investigate clinical feasibility and translation.
methodsEighteen MS patients and nine age- and sex-matched healthy controls (HCs) underwent a 3.0 Tesla scan inclusive of clinical sequences and SMT images (isotropic resolution of 2 mm). Axial diffusivity (AD), apparent axonal volume fraction (V
resultsDifferences were seen in all SMT-derived parameters between chronic black holes (cBHs) and T2-lesions (P ≤ 0.0016), in V INTERPRETATIONS: SMT-derived metrics are sensitive to pathological changes and hold potential for clinical application in MS patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.