Evidence map›Paper›PMID 31407531›Full record

SynthesisMolecular genetics & genomic medicine2019

Genome-wide meta-analysis of SNP and antihypertensive medication interactions on left ventricular traits in African Americans.

Anh N Do, Wei Zhao, Abigail S Baldridge, Laura M Raffield, Kerri L Wiggins, Sanjiv J Shah, Stella Aslibekyan, Hemant K Tiwari, Nita Limdi, Degui Zhi and 15 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Genetic approaches toward understanding the individual variation in cardiac structure, function and responses to exercise training.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 13 institutions in 1 country.

Anh N DoDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-3316-9887
Wei ZhaoDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Abigail S BaldridgeFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Laura M RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
Kerri L WigginsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Sanjiv J ShahFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Stella AslibekyanDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Hemant K TiwariDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Nita LimdiDepartment of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Degui ZhiSchool of Biomedical Informatics, University of Texas Health Sciences Center at Houston, Houston, Texas, USA.
Colleen M SitlaniCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Kent D TaylorDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Seattle, Washington, USA.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington, USA.
Nona SotoodehniaCardiovascular Health Research Unit, Division of Cardiology, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, USA.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Laura J Rasmussen-TorvikDepartment of Preventive Medicine Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Donald Lloyd-JonesFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Leslie A LangeDepartment of Medicine, University of Colorado Denver, Aurora, Colorado, USA.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Jennifer A SmithDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Sharon L R KardiaDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Thomas H MosleyDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Ramachandran S VasanDepartments of Medicine and Preventive Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Donna K ArnettCollege of Public Health, University of Kentucky, Lexington, Kentucky, USA.
Marguerite R IrvinDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
University of Alabama at Birmingham · USNorthwestern University · USUniversity of Washington · USUniversity of Michigan · USBoston University · USHarbor–UCLA Medical Center · USJackson Memorial Hospital · USKaiser Permanente Washington Health Research Institute · USThe University of Texas Health Science Center at Houston · USUniversity of Colorado Denver · USUniversity of Kentucky · USUniversity of Mississippi Medical Center · USUniversity of North Carolina at Chapel Hill · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
A Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
HYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHYR01HL055673 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNETT, DONNA K · 1996 to 2016
$18.1M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Genome-wide case-only study of antihypertensive drug-gene interactionsR01HL085251 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2007 to 2010
$7.2M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
Genome Wide Association Coordinating CenterU01HG004446 · NHGRI · UNIVERSITY OF WASHINGTON · PI WEIR, BRUCE S. · 2007 to 2011
$6.6M
Prospective meta-analyses of drug-gene interactions: CHARGE GWAS consortiumR01HL103612 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2011 to 2014
$5.4M
WGA Study to Identify Genetic Variants Associated with CV Events in CHSR01HL087652 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2007 to 2009
$5.1M
NCATS NIH HHS UL1 TR000124NHGRI NIH HHS U01 HG004446NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS N01 HC065226NHLBI NIH HHS N01HC55222NHLBI NIH HHS N01HC85079NHLBI NIH HHS N01HC85080NHLBI NIH HHS N01HC85081NHLBI NIH HHS N01HC85082NHLBI NIH HHS N01HC85083NHLBI NIH HHS N01HC85086NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL119443NHLBI NIH HHS T32 HL129982NHLBI NIH HHS U01 HL054509NHLBI NIH HHS U01 HL130114NHLBI NIH HHS U10 HL054509NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

backgroundLeft ventricular (LV) hypertrophy affects up to 43% of African Americans (AAs). Antihypertensive treatment reduces LV mass (LVM). However, interindividual variation in LV traits in response to antihypertensive treatments exists. We hypothesized that genetic variants may modify the association of antihypertensive treatment class with LV traits measured by echocardiography.

methodsWe evaluated the main effects of the three most common antihypertensive treatments for AAs as well as the single nucleotide polymorphism (SNP)-by-drug interaction on LVM and relative wall thickness (RWT) in 2,068 participants across five community-based cohorts. Treatments included thiazide diuretics (TDs), angiotensin converting enzyme inhibitors (ACE-Is), and dihydropyridine calcium channel blockers (dCCBs) and were compared in a pairwise manner. We performed fixed effects inverse variance weighted meta-analyses of main effects of drugs and 2.5 million SNP-by-drug interaction estimates.

resultsWe observed that dCCBs versus TDs were associated with higher LVM after adjusting for covariates (p = 0.001). We report three SNPs at a single locus on chromosome 20 that modified the association between RWT and treatment when comparing dCCBs to ACE-Is with consistent effects across cohorts (smallest p = 4.7 × 10

conclusionsOur study identified one locus having genome-wide significant SNP-by-drug interaction effect on RWT among dCCB users in comparison to ACE-I users. Upon additional validation in future studies, our findings can enhance the precision of medical approaches in hypertension treatment.

Indexed as

Pharmacogenomic VariantsPolymorphism, Single NucleotideAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsBlack or African AmericanCalcium Channel BlockersHumansObservational Studies as TopicSodium Chloride Symporter InhibitorsVentricular Dysfunction, LeftAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsCalcium Channel BlockersSodium Chloride Symporter Inhibitorsantihypertensive treatmentGWASleft ventricular traitpharmacogenetics

Identifiers

PMID31407531
PMCPMC6785453
OpenAlexW2967975550

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.