ArticleJournal of biophotonics2019
Parallelized shifted-excitation Raman difference spectroscopy for fluorescence rejection in a temporary varying system.
Article in Journal of biophotonics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- 10 kHz Shifted-Excitation Raman Difference Spectroscopy with Charge-Shifting Charge-Coupled Device Read-Out for Effective Mitigation of Dynamic Interfering Backgrounds.Applied spectroscopy · 2023Article
- Looking for a perfect match: multimodal combinations of Raman spectroscopy for biomedical applications.Journal of biomedical optics · 2021Review
- Parallelized shifted-excitation Raman difference spectroscopy for fluorescence rejection in a temporary varying system.Journal of biophotonics · 2019Article
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Authors and funding
3 authors.
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Abstract
A fluorescence background is one of the common interference factors of the Raman spectroscopic analysis in the biology field. Shifted-excitation Raman difference spectroscopy (SERDS), in which a slow (typically 1 Hz) modulation to excitation wavelength is coupled with a sequential acquisition of alternating shifted-excitation spectra, has been used to separate Raman scattering from excitation-shift insensitive background. This sequential method is susceptible to spectral change and thus is limited only to stable samples. We incorporated a fast laser modulation (200 Hz) and a mechanical streak camera into SERDS to effectively parallelize the SERDS measurement in a single exposure. The developed system expands the scope of SERDS to include temporary varying system. The proof of concept is demonstrated using highly fluorescent samples, including living algae. Quantitative performance in fluorescence rejection and the robustness of the method to the dynamic spectral change during the measurement are manifested.
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