ArticlePediatric blood & cancer2020
Neuroanatomical abnormalities related to dexamethasone exposure in survivors of childhood acute lymphoblastic leukemia.
Article in Pediatric blood & cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Structural and Functional Brain Imaging in Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia Treated With Chemotherapy: A Systematic Review.JNCI cancer spectrum · 2021Pooled it
- Attention and executive functioning in children and adolescents treated for high-risk acute lymphoblastic leukemia: A report from the Children's Oncology Group (COG).Pediatric blood & cancer · 2024Trial
- Pediatric cancer in western China: a cross-sectional analysis of cognitive impairment.BMC pediatrics · 2025Article
- Article
- Neuropsychological function in childhood cancer patients and adult survivors of childhood cancer.Journal of clinical and experimental neuropsychology · 2025Review
- Establishment and application of an intelligent management platform for home medication for children with leukemia.PloS one · 2025Article
- Progression of brain injuries associated with methotrexate chemotherapy in childhood acute lymphoblastic leukemia.Pediatric research · 2025Article
- Article
- Clinical Potential of Transcranial Focused Ultrasound for Neurorehabilitation in Pediatric Cancer Survivors.Brain sciences · 2024Review
- Late-onset Cognitive Impairment and Modifiable Risk Factors in Adult Childhood Cancer Survivors.JAMA network open · 2023Article
- [Recent research on cognitive impairment in children with acute lymphoblastic leukemia].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Review
- Article
- Article
- Sex-Based Differences in Functional Brain Activity During Working Memory in Survivors of Pediatric Acute Lymphoblastic Leukemia.JNCI cancer spectrum · 2022Article
- FreeSurfer-based segmentation of hippocampal subfields: A review of methods and applications, with a novel quality control procedure for ENIGMA studies and other collaborative efforts.Human brain mapping · 2022Review
- Neurotoxic Effects of Childhood Cancer Therapy and Its Potential Neurocognitive Impact.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021Review
- Brain Imaging in Pediatric Cancer Survivors: Correlates of Cognitive Impairment.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021Review
- Article
- Neurocognitive and Behavioral Outcomes of Chinese Survivors of Childhood Lymphoblastic Leukemia.Frontiers in oncology · 2021Article
- Cognitive Rehabilitation for Neurocognitive Late Effects in Adult Survivors of Childhood Acute Lymphoblastic Leukemia: A Feasibility and Case-Series Study.Frontiers in psychology · 2021Article
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12 authors at 2 institutions in 2 countries.
Funding
Abstract
Survivors of childhood acute lymphoblastic leukemia (ALL) treated with chemotherapy only are at risk for neurocognitive impairment. Regions of interest were identified a priori based on glucocorticoid receptor distribution, and sex-stratified multivariable linear regression models were used to test associations between brain MRI morphology and total number of intrathecal injections, and serum concentration of dexamethasone and methotrexate. Compared with controls, ALL survivors have persistently smaller volumes in the bilateral cerebellum (P < 0.005), hippocampal subregions (P < 0.03), temporal lobe regions (P < 0.03), frontal lobe regions (P < 0.04), and parietal lobe regions (precuneus; P < 0.002). Long-term problems with learning may be related to residual posttreatment brain differences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.