Evidence map›Paper›PMID 31407271›Full record

ArticleDrug delivery and translational research2020

The study of ultrasound and iontophoresis on oxaprozin transdermal penetration using surface-enhanced Raman spectroscopy.

Shupeng Liu, Xiang Bao, Songpo Zhang, Heng Zhang, Xiaofeng Lu, Taihao Li, Zhenyi Chen, Na Chen

Abstract read
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In one paragraph

Article in Drug delivery and translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shupeng LiuKey Laboratory of Specialty Fiber Optics and Optical Access Networks, Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication, Shanghai Institute for Advanced Communication and Data Science, Institute of Biomedical Engineering, School of Communication and Information Engineering, Shanghai University, 333 Nanchen Road, Shanghai, 200444, China. liusp@shu.edu.cn.
Xiang BaoKey Laboratory of Specialty Fiber Optics and Optical Access Networks, Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication, Shanghai Institute for Advanced Communication and Data Science, Institute of Biomedical Engineering, School of Communication and Information Engineering, Shanghai University, 333 Nanchen Road, Shanghai, 200444, China.
Songpo ZhangKey Laboratory of Specialty Fiber Optics and Optical Access Networks, Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication, Shanghai Institute for Advanced Communication and Data Science, Institute of Biomedical Engineering, School of Communication and Information Engineering, Shanghai University, 333 Nanchen Road, Shanghai, 200444, China.
Heng ZhangKey Laboratory of Specialty Fiber Optics and Optical Access Networks, Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication, Shanghai Institute for Advanced Communication and Data Science, Institute of Biomedical Engineering, School of Communication and Information Engineering, Shanghai University, 333 Nanchen Road, Shanghai, 200444, China.
Xiaofeng LuKey Laboratory of Specialty Fiber Optics and Optical Access Networks, Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication, Shanghai Institute for Advanced Communication and Data Science, Institute of Biomedical Engineering, School of Communication and Information Engineering, Shanghai University, 333 Nanchen Road, Shanghai, 200444, China.
Taihao LiCollege of Medical Instruments, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.
Zhenyi ChenKey Laboratory of Specialty Fiber Optics and Optical Access Networks, Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication, Shanghai Institute for Advanced Communication and Data Science, Institute of Biomedical Engineering, School of Communication and Information Engineering, Shanghai University, 333 Nanchen Road, Shanghai, 200444, China.
Na ChenKey Laboratory of Specialty Fiber Optics and Optical Access Networks, Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication, Shanghai Institute for Advanced Communication and Data Science, Institute of Biomedical Engineering, School of Communication and Information Engineering, Shanghai University, 333 Nanchen Road, Shanghai, 200444, China. na.chen@shu.edu.cn.
Shanghai University · CNShanghai University of Medicine and Health Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The potential for physicochemical driving forces facilitating topical transport of the lipid-soluble drug oxaprozin (OXA) was investigated using surface-enhanced Raman spectroscopy (SERS) in this study. Azone, iontophoresis (IP), and sonophoresis (SP) were combined and performed on mouse skin for the OXA transdermal penetration, and the synergistic effect was analyzed using Raman spectroscopy. The data of characteristic peak intensity were processed with overlapping peak resolving and standard normalization. The results showed that Azone promoted the transdermal penetration of OXA (5.9-fold greater than the OXA concentration of normal penetration); SP enhanced OXA transdermal penetration (5.5-fold); IP enhanced OXA transdermal penetration (4.2-fold); the combined application of Azone and SP (Azone+SP) and SP+IP can improve the enhancement coefficient of OXA transdermal penetration (8.4-fold and 6.1-fold, > 5.9, > 5.5, > 4.2), and their combined application has a synergistic effect; Azone+IP does not have a synergistic effect while the enhancement coefficient of Azone+IP (5.3-fold, < 5.9) and Azone+SP+IP (7.2-fold, < 8.4) was slightly reduced. As for the drug OXA, Azone+SP is an effective method of transdermal penetration.

Indexed as

Administration, CutaneousAnimalsAzepinesIontophoresisMaleMiceOxaprozinPermeabilitySkin AbsorptionSpectrum Analysis, RamanUltrasonographyAzepineslaurocapramOxaprozinAzoneIontophoresisOxaprozinRaman spectrumSonophoresisTransdermal

Identifiers

PMID31407271
OpenAlexW2967898251

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.