Observational studyJournal of endocrinological investigation2020
The clinical phenotype of Graves' disease occurring as an isolated condition or in association with other autoimmune diseases.
Observational study in Journal of endocrinological investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Change in newly diagnosed Graves' disease phenotype between the twentieth and the twenty-first centuries: meta-analysis and meta-regression.Journal of endocrinological investigation · 2021Pooled it
- Different clinical autoimmune polyglandular syndrome phenotypes among patients with thyroid diseases.Journal of endocrinological investigation · 2026Article
- Clinical and Ultrasonographic Characterization of the Transition from Hashimoto Thyroiditis to Graves' Disease: A Long-term Follow-up Study.Endocrine · 2026Article
- Thyroid eye disease in the context of autoimmune polyglandular syndromes: comparative clinical insights from a retrospective study.Frontiers in endocrinology · 2026Article
- Clinical Phenotype of Graves Disease in Autoimmune Polyglandular Syndrome or as Isolated Disease: The GRAPHE Study.The Journal of clinical endocrinology and metabolism · 2025Observational
- Article
- Article
- Type 3 autoimmune polyglandular syndrome (APS-3) or type 3 multiple autoimmune syndrome (MAS-3): an expanding galaxy.Journal of endocrinological investigation · 2023Review
- Epitopes specificity of antibodies to thyroid peroxidase in patients with Graves' disease, Hashimoto's thyroiditis and overlap-syndrome.Journal of clinical & translational endocrinology · 2022Article
- Radioactive Iodine for the Treatment of Subclinical Thyrotoxicosis Grade 1 and 2: Outcome of up to 18-Year Follow Up.Frontiers in endocrinology · 2022Article
- Analysis of the Application Value of Ultrasound Three-Dimensional Speckle Tracking Technology Combined with Thyroid Autoantibodies and Hormones in the Diagnosis and Treatment of Graves' Disease.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- The new generation PFAS C6O4 does not produce adverse effects on thyroid cells in vitro.Journal of endocrinological investigation · 2021Article
- Levothyroxine and insulin requirement in autoimmune polyglandular type 3 syndrome: a real-life study.Journal of endocrinological investigation · 2021Article
- Correlation between serum anti-TSH receptor autoantibodies (TRAbs) and the clinical feature of Graves' orbitopathy.Journal of endocrinological investigation · 2021Article
- Clinical phenotype of Graves' disease.Journal of endocrinological investigation · 2020Article
- Gender differences in pharmacokinetics of perfluoropentanoic acid using non-linear mixed-effect modeling in rats.Archives of toxicology · 2020Article
- Epidemiology, Natural History, Risk Factors, and Prevention of Graves' Orbitopathy.Frontiers in endocrinology · 2020Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGraves' disease (GD) can present as an isolated disease (iGD) or in association with other autoimmune diseases (aGD). The aim of this study, performed in two Endocrine referral centers settled in different geographical areas of Italy, was to compare the anthropometric, clinical, and biochemical phenotype of iGD patients with that of the aGD ones.
methodsClinical history, physical examination data, serum levels of TSH, FT4, FT3, thyroglobulin (TgAb), thyroid-peroxidase (TPOAb) and TSH-receptor (TRAb) antibody, presence of Graves' orbitopathy (GO), and thyroid ultrasound examination at disease diagnosis were recorded.
results68 aGD and 136 iGD patients were consecutively recruited. At diagnosis, aGD and iGD patients did not differ for F/M ratio, age at presentation, thyroid function parameters, serum levels of TRAb, TgAb, TPOAb, presence of GO, and thyroid volume. The serum levels of TRAb were strongly correlated with the circulating concentrations of both FT3 (ρ = 0.667; p < 0.0001) and FT4 (ρ = 0.628; p < 0.001) in iGD patient, but not in the aGD ones (FT3: ρ = 0.231; p = 0.058; FT4: ρ = 0.096; p = 0.435). Compared with iGD patients, the aGD ones displayed a higher rate of transition from the previous hypothyroidism to hyperthyroidism (χ
conclusionDespite similar anthropometric, clinical, and biochemical features at diagnosis, aGD patients display a higher rate of transition from a thyroid functional status to the other as compared with iGD patients.
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