Evidence map›Paper›PMID 31407187›Full record

ArticleJournal of youth and adolescence2020

Exploring how Family and Neighborhood Stressors Influence Genetic Risk for Adolescent Conduct Problems and Alcohol Use.

Cristina B Bares, Karen G Chartier, Katherine J Karriker-Jaffe, Fazil Aliev, Brian Mustanski, Danielle Dick

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of youth and adolescence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cristina B BaresSchool of Social Work, University of Michigan, 1080S. University, Ann Arbor, MI, 48109, USA. cbb@umich.edu.
Karen G ChartierSchool of Social Work and Department of Psychiatry, Virginia Commonwealth University, 1000 Floyd Avenue, P.O. Box 842027, Richmond, VA, 23284, USA.
Katherine J Karriker-JaffeAlcohol Research Group, Public Health Institute, 6001 Shellmound St., Suite 450, Emeryville, CA, 94608, USA.
Fazil AlievDepartment of Psychology, Virginia Commonwealth University, 817W. Franklin, Suite B-16, Richmond, VA, 23284, USA.
Brian MustanskiDepartment of Medical Social Sciences, Northwestern University, 625N. Michigan Avenue, Suite 14-061, Chicago, IL, 60611, USA.
Danielle DickDepartment of Psychology, Virginia Commonwealth University, 800W. Franklin, Room 202, Richmond, VA, 23284, USA.

Funding

Social, Developmental and Genetic Epidemiology of Alcohol Use DisordersR01AA023534 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI KENDLER, KENNETH SEEDMAN, SUNDQUIST, KRISTINA · 2015 to 2023
$4.0M
Gene-Environment Interaction Effects on HIV RiskR01DA025039 · NIDA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MUSTANSKI, BRIAN · 2008 to 2012
$2.6M
Twin, molecular, and developmental approaches to understanding alcohol misuseK02AA018755 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M · 2010 to 2019
$1.3M
Genetic Contributions to Smoking and Internalizing Problems in AdolescenceK01DA036681 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI BARES, CRISTINA B. · 2014 to 2018
$755k
Ethnicity and alcohol dependence: Phenotypes, genes, and the social environmentK01AA021145 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI CHARTIER, KAREN G. · 2012 to 2016
$536k
NIAAA NIH HHS K01 AA021145NIAAA NIH HHS K02 AA018755NIAAA NIH HHS R01 AA023534NIDA NIH HHS K01 DA036681NIDA NIH HHS R01 DA025039
6 · The paper itself

Abstract

Previous research suggests that genetic risk factors may predispose to conduct problems and alcohol use in adolescence. Whether genetic risk factors interact with social contexts has not been well characterized among African American adolescents. Data came from a subsample of the Genes, Environment, and Neighborhood Initiative study comprising 501 African American adolescents, including 151 lifetime drinkers (56% female, mean age = 16.3, SD = 1.4). Genetic risk was assessed with polygenic risk scores for alcohol dependence. Analyses explored interactions between genetic risk and self-reported alcohol use, conduct problems, life stressors, and other covariates. The effects of two gene-environment interactions (G × E) were tested in the sample of alcohol exposed adolescents; one on conduct problems and the other on alcohol use. There were significant associations between polygenic risk for alcohol dependence and conduct problems. A significant G × E interaction showed the impact of genetic risk on conduct problems was stronger under conditions of high exposure to family and neighborhood stressors. Among this sample of African American adolescents, genetic risk for alcohol dependence was not directly associated with alcohol use but was related to more conduct problems. Further, the effect of genetic risk interacted with stressors from the family and neighborhood, so that the effect of genetic risk on conduct problems was stronger for individuals who reported greater stressors.

Indexed as

Genetic Predisposition to DiseaseResidence CharacteristicsAdolescentAdolescent BehaviorAlcoholismAlcohol-Related DisordersBlack or African AmericanConduct DisorderFemaleGene-Environment InteractionHumansMaleProblem BehaviorRisk FactorsSocial EnvironmentSocioeconomic FactorsAdolescentsAlcohol useConduct problemsExposure to stressorsGenetic risk

Identifiers

PMID31407187
PMCPMC7012717

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.