ArticleInternational journal of clinical oncology2020
Risk factors and prognostic significance of lateral pelvic lymph node metastasis in advanced rectal cancer.
Article in International journal of clinical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Risk factors for lateral pelvic lymph node metastasis in patients with lower rectal cancer: a systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- MRI for prognosis prediction of T3-stage rectal cancer based on "DISTANCE" structural report.Abdominal radiology (New York) · 2026Article
- Predictive Study of Machine Learning-Based Multiparametric MRI Radiomics Nomogram for Perineural Invasion in Rectal Cancer: A Pilot Study.Journal of imaging informatics in medicine · 2025Article
- Who is a candidate at the initial presentation? Prediction of positive lateral lymph node and survival after dissection.Techniques in coloproctology · 2025Review
- Lateral node metastasis in low rectal cancer as a hallmark to predict recurrence patterns.International journal of clinical oncology · 2024Article
- The role of lateral pelvic lymph node dissection in advanced rectal cancer: a review of current evidence and outcomes.Annals of coloproctology · 2024Review
- Efficacy of lateral lymph node dissection for local control of rectal cancer: A multicenter study.Annals of gastroenterological surgery · 2024Article
- A combined diagnostic model including middle rectal artery visualization for predicting lateral lymph node metastasis in rectal cancer.Frontiers in physiology · 2024Article
- Article
- A nomogram and risk classification system forecasting the cancer-specific survival of lymph- node- positive rectal cancer patient after radical proctectomy.Frontiers in oncology · 2023Article
- Clinical Relevance of Lateral Pelvic Lymph Node Dissection for Enlarged Lateral Nodes in Locally Advanced Low Rectal Cancer without Preoperative Treatment.Journal of the anus, rectum and colon · 2023Article
- Optimization of therapeutic strategies for selective lateral lymph node dissection after neoadjuvant chemoradiotherapy in patients with rectal cancer with clinical suspected lateral lymph node metastasis.Frontiers in oncology · 2023Article
- Development and External Validation of a Preoperative Nomogram for Predicting Lateral Pelvic Lymph Node Metastasis in Patients With Advanced Lower Rectal Cancer.Frontiers in oncology · 2022Article
- Preoperative Prediction of Perineural Invasion Status of Rectal Cancer Based on Radiomics Nomogram of Multiparametric Magnetic Resonance Imaging.Frontiers in oncology · 2022Article
- Article
- Therapeutic significance of D3 dissection for low rectal cancer: a comparison of dissections between the lateral pelvic lymph nodes and the lymph nodes along the root of the inferior mesenteric artery in a multicenter retrospective cohort study.International journal of colorectal disease · 2021Article
- Clinical characteristics and predictors of permanent stoma in rectal cancer patients underwent anterior resections: the value of preoperative prognostic nutritional index.International journal of clinical oncology · 2020Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to elucidate the risk factors for and prognostic value of lateral pelvic lymph node (LPLN) metastasis in advanced rectal cancer patients, including those with stage IV disease.
methodsThe treatment outcomes of 78 patients with advanced rectal cancer, the lower margin of which was located at or below the peritoneal reflection, who underwent curative-intent surgery with bilateral LPLN dissection from 2005 to 2018 were retrospectively analyzed.
resultsIn total, 78 rectal cancer patients, including 13 patients with stage IV tumors, 9 patients (11.5%) had LPLN metastasis. A multivariate analysis to identify preoperative clinical factors associated with LPLN metastasis showed that tumor location (below the peritoneal reflection: Rb), LPLN metastasis on preoperative imaging and distant metastasis were independent predictors of LPLN metastasis. In addition, metastasis at the regional lymph nodes in the mesorectum was significantly associated with LPLN metastasis. Both the disease-free survival (DFS) and cancer-specific survival (CSS) of patients with LPLN metastasis were significantly worse in comparison to patients without LPLN metastasis, and the CSS of stage IV patients with LPLN metastasis was significantly worse in comparison to stage IV patients without LPLN metastasis.
conclusionsTumor location (Rb), LPLN metastasis on preoperative imaging and distant metastasis were risk factors for LPLN metastasis. The prognosis of rectal cancer patients with LPLN metastasis is poor. There may not be the indication of LPLN dissection in stage IV lower rectal cancer except cases having complaints due to LPLN metastasis.
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