Evidence map›Paper›PMID 31407157›Full record

ArticleImmunologic research2019

Comparison of immunomodulatory properties of exosomes derived from bone marrow mesenchymal stem cells and dental pulp stem cells.

Lujun Ji, Liuliu Bao, Zhifeng Gu, Qiao Zhou, Yi Liang, Ya Zheng, Yang Xu, Xiang Zhang, Xingmei Feng

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Immunologic research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 120 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. The Therapeutic Scope of Orofacial Mesenchymal Stem Cells.Bioengineering (Basel, Switzerland) · 2025
    Review
  9. Therapeutic nanoparticle safety in pregnancy: Bridging knowledge gaps with environmental insights and a translational roadmap.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Review
  10. Isolation methods of exosomes derived from dental stem cells.International journal of oral science · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lujun JiDepartment of Stomatology, Nantong Tongzhou People's Hospital, Nantong, 226001, China.
Liuliu BaoDepartment of Stomatology, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Zhifeng GuResearch Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Qiao ZhouDepartment of Stomatology, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Yi LiangDepartment of Stomatology, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Ya ZhengDepartment of Stomatology, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Yang XuDepartment of Stomatology, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Xiang ZhangDepartment of Stomatology, Haian People's Hospital of Jiangsu Province, Nantong, 226001, China.
Xingmei FengDepartment of Stomatology, Affiliated Hospital of Nantong University, Nantong, 226001, China. Xingmeifeng@ntu.edu.cn.ORCID http://orcid.org/0000-0002-2063-5885
Nantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Substantial discoveries suggested that exosomes released from multiple sources of stem cells can affect the biological functions of target cells. In present period, the immunosuppressive properties of exosomes derived from bone marrow mesenchymal stem cells (BMMSCs-E) have been extensively recognized, but few studies have been reported about exosomes secreted from dental pulp stem cells (DPSCs-E) in the field of medical immunity. Hence, the aim of this study is to compare the immunomodulatory capacity of BMMSCs-E and DPSCs-E. Peripheral blood mononuclear cells (PBMCs) were co-cultured with them respectively and the proportion of regulatory T cells (Treg) was detected to increase. Subsequently, we stimulated CD4+T cells with BMMSCs-E and DPSCs-E to observe their effects on the polarizations, chemokines secretion, apoptosis, and proliferation of CD4+T cells. We found that DPSCs-E inhibited the differentiation of CD4+T cells into T helper 17 cells (Th17) and reduced the secretions of pro-inflammatory factors IL-17 and TNF-α, while promoted the polarization of CD4+T cells into Treg and increased the release of anti-inflammatory factors IL-10 and TGF-β. What's more, these capabilities of DPSCs-E were stronger than those of BMMSCs-E. In addition, DPSCs-E were more effective in inducing apoptosis of CD4+T cells compared with BMMSCs-E, and DPSCs-E inhibited the proliferation of CD4+T cells, which is similar to BMMSCs-E. We draw a conclusion that DPSCs-E have stronger immune-modulating activities than BMMSCs-E, and may be a new therapeutic tool for the treatment of immunological diseases.

Indexed as

ImmunomodulationAdultBone Marrow CellsCell DifferentiationCell ProliferationDental PulpExosomesFemaleHumansInterleukin-10MaleMesenchymal Stem CellsTh17 CellsT-Lymphocytes, RegulatoryTransforming Growth Factor betaIL10 protein, humanInterleukin-10Transforming Growth Factor betaBone marrow mesenchymal stem cellsCD4+T cellsDental pulp stem cellsExosomesImmunomodulatory

Identifiers

PMID31407157
OpenAlexW2966924715

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.