ArticleJournal of the Association for Research in Otolaryngology : JARO2019
Morphological Immaturity of the Neonatal Organ of Corti and Associated Structures in Humans.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Single-dose genome editing therapy rescues auditory and vestibular functions in adult mice with DFNA41 deafness.The Journal of clinical investigation · 2025Article
- Single Administration of AAV-mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2-Induced Lysosomal Dysfunction in Hair Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- 3D Computational Modeling of Blast Transmission through the Fluid-Filled Cochlea and Hair Cells.Annals of biomedical engineering · 2025Article
- Inner Ear Organoids: Strengths and Limitations.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Deafness: from genetic architecture to gene therapy.Nature reviews. Genetics · 2023Review
- Models of Cochlea Used in Cochlear Implant Research: A Review.Annals of biomedical engineering · 2023Review
- Organ of Corti vibrations are dominated by longitudinal motion in vivo.Communications biology · 2022Article
- Cochlear Fluid Spaces and Structures of the Gerbil High-Frequency Region Measured Using Optical Coherence Tomography (OCT).Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Recent advancements in cell-based models for auditory disorders.BioImpacts : BI · 2022Review
- Spontaneous otoacoustic emissions are biomarkers for mice with tectorial membrane defects.Hearing research · 2021Article
- Postnatal structural development of mammalian Basilar Membrane provides anatomical basis for the maturation of tonotopic maps and frequency tuning.Scientific reports · 2021Article
- Extended low-frequency phase of the distortion-product otoacoustic emission in human newborns.JASA express letters · 2021Article
- The cochlear ear horn: geometric origin of tonotopic variations in auditory signal processing.Scientific reports · 2020Article
- Anatomy of the Human Osseous Spiral Lamina and Cochlear Partition Bridge: Relevance for Cochlear Partition Motion.Journal of the Association for Research in Otolaryngology : JARO · 2020Article
- Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Although anatomical development of the cochlear duct is thought to be complete by term birth, human newborns continue to show postnatal immaturities in functional measures such as otoacoustic emissions (OAEs). Some of these OAE immaturities are no doubt influenced by incomplete maturation of the external and middle ears in infants; however, the observed prolongation of distortion-product OAE phase-gradient delays in newborns cannot readily be explained by conductive factors. This functional immaturity suggests that the human cochlea at birth may lack fully adult-like traveling-wave motion. In this study, we analyzed temporal-bone sections at the light microscopic level in newborns and adults to quantify dimensions and geometry of cochlear structures thought to influence the mechanical response of the cochlea. Contrary to common belief, results show multiple morphological immaturities along the length of the newborn spiral, suggesting that important refinements in the size and shape of the sensory epithelium and associated structures continue after birth. Specifically, immaturities of the newborn basilar membrane and organ of Corti are consistent with a more compliant and less massive cochlear partition, which could produce longer DPOAE delays and a shifted frequency-place map in the neonatal ear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.