Evidence map›Paper›PMID 31407028›Full record

ArticleActa neuropathologica2019

Alpha-synuclein: prion or prion-like?

Rehana K Leak, Matthew P Frosch, Thomas G Beach, Glenda M Halliday

Abstract readLetter
In one paragraph

Article in Acta neuropathologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Rab27b Promotes Lysosomal Function and Alpha-Synuclein Clearance in Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Is Multiple System Atrophy a Prion-like Disorder?International journal of molecular sciences · 2021
    Review
  11. Article
  12. Disruption of cellular proteostasis by H1N1 influenza A virus causes α-synuclein aggregation.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rehana K LeakPharmaceutical Sciences Division, Graduate School of Pharmaceutical Sciences, Duquesne University, 407 Mellon Hall, Pittsburgh, PA, 15282, USA. leakr@duq.edu.ORCID 0000-0003-2817-7417
Matthew P FroschC.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Thomas G BeachCivin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, 10515, USA.
Glenda M HallidayBrain and Mind Centre and Central Clinical School, University of Sydney, Sydney, NSW, 2050, Australia.

Funding

Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie · 2019 to 2026
$36.5M
Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI GONZALEZ HERNANDEZ, GRACIELA · 2001 to 2020
$32.5M
National Brain and Tissue Resource for Parkinson's Disease and Related DisordersU24NS072026 · NINDS · BANNER SUN HEALTH RESEARCH INSTITUTE · PI BEACH, THOMAS G · 2011 to 2015
$7.8M
The Impact of Heat Shock Protein 70 on Lewy Body DisordersR21NS107960 · NINDS · DUQUESNE UNIVERSITY · PI LEAK, REHANA KHAN · 2018 to 2019
$415k
Impact of N-acetyl cysteine ethyl ester on a-synuclein pathology in the olfactory systemR15NS093539 · NINDS · DUQUESNE UNIVERSITY · PI LEAK, REHANA KHAN · 2015 to 2015
$383k
National Health and Medical Research Council 1079679NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG062421NIH HHS 1R15NS093539NIH HHS 1R21NS107960NIH HHS P30AG062421NIH HHS P30AG19610NIH HHS U24NS072026NINDS NIH HHS R15 NS093539NINDS NIH HHS R21 NS107960NINDS NIH HHS U24 NS072026
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

alpha-SynucleinAnimalsBrainHumansPrionsalpha-SynucleinPrions

Identifiers

PMID31407028
PMCPMC6778512

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.