Evidence map›Paper›PMID 31407017›Full record

ArticleHNO2019

[Immunodeficiency in chronic rhinosinusitis : An important and often underestimated cause].

L Klimek, A Chaker, C Matthias, A Sperl, P Gevaert, P Hellings, B Wollenberg, M Koennecke, J Hagemann, J Eckrich and 1 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in HNO, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

L KlimekZentrum für Rhinologie und Allergologie Wiesbaden, An den Quellen 10, 65183, Wiesbaden, Deutschland. Ludger.Klimek@Allergiezentrum.org.
A ChakerKlinik für Hals-Nasen-Ohrenheilkunde und Zentrum für Allergie und Umwelt, Klinikum rechts der Isar, Technische Universität München, München, Deutschland.
C MatthiasHals-, Nasen-, Ohrenklinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Deutschland.
A SperlZentrum für Rhinologie und Allergologie Wiesbaden, An den Quellen 10, 65183, Wiesbaden, Deutschland.
P GevaertKlinik für Hals-Nasen-Ohren-Heilkunde, Universitätsklinik Ghent, Ghent, Belgien.
P HellingsKlinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, University of Leuwen, Leuwen, Belgien.
B WollenbergKlinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Schleswig-Holstein, Lübeck, Deutschland.
M KoenneckeKlinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Schleswig-Holstein, Lübeck, Deutschland.
J HagemannHals-, Nasen-, Ohrenklinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Deutschland.
J EckrichHals-, Nasen-, Ohrenklinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Deutschland.
S BeckerKlinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, Universitätsklinikum Tübingen, Tübingen, Deutschland.
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde · DEJohannes Gutenberg University Mainz · DEZentrum für Rhinologie und Allergologie · DEKlinikum rechts der Isar · DEKlinik und Poliklinik für Psychosomatische Medizin und Psychotherapie · DEUniversitätsklinik für Hals-, Nasen- und Ohrenheilkunde · DEUniversity Hospital Schleswig-Holstein · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic rhinosinusitis (CRS) is one of the most frequent chronic diseases. Among these patients the prevalence of immune defects is higher than in the healthy general population.

methodsA selective review of the literature was carried out in PubMed and Medline covering the period between 2008 and 2019. Additionally, recent German publications in journals not listed in the abovementioned databases were analyzed.

resultsThe diagnostic workflow with respect to the immunodeficiency consists of a detailed anamnesis and physical examination, laboratory tests and the antibody reaction to polysaccharide vaccines and antigens. Beside antibiotic treatment, vaccinations and immunoglobulin replacement are available. Notwithstanding the above, functional endoscopic surgery of the paranasal sinuses should be performed according to guideline recommendations.

conclusionPatients with CRS who do not sufficiently respond to conservative and surgical treatment should be checked for underlying immunodeficiencies.

Indexed as

Immune System DiseasesParanasal SinusesRhinitisSinusitisChronic DiseaseEndoscopyHumansCommon variable immunodeficiencyImmunoglobulinsNasal mucosaParanasal sinusesSpecific antibody deficiency

Identifiers

PMID31407017
OpenAlexW2967934823

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.