ArticleGenome biology and evolution2019
Unique DNA Methylation Profiles Are Associated with cis-Variation in Honey Bees.
Article in Genome biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- DNA Methylation Reflects Cis-Genetic Differentiation Across the European Crow Hybrid Zone.Molecular ecology · 2025Article
- Epigenetic Mechanisms inCurrent issues in molecular biology · 2025Review
- Climate change-induced stress in the honey beeFrontiers in physiology · 2025Review
- A tool for rapid, automated characterization of population epigenomics in plants.Scientific reports · 2023Article
- H3K4me1 Modification Functions in Caste Differentiation in Honey Bees.International journal of molecular sciences · 2023Article
- Screening bioactive food compounds in honey bees suggests curcumin blocks alcohol-induced damage to longevity and DNA methylation.Scientific reports · 2021Article
- Atypical DNA methylation, sRNA-size distribution, and female gametogenesis in Utricularia gibba.Scientific reports · 2021Article
- Still no evidence for transgenerational inheritance or absence of epigenetic reprogramming in the honey bee.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Reply to Soley: DNA methylation marks are stably transferred across generations in honey bees.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Parent-of-origin effects, allele-specific expression, genomic imprinting and paternal manipulation in social insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Review
- Intergenerational transfer of DNA methylation marks in the honey bee.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Epigenetic Molecular Mechanisms in Insects.Neotropical entomology · 2020Review
- Bumblebee Workers Show Differences in Allele-Specific DNA Methylation and Allele-Specific Expression.Genome biology and evolution · 2020Article
- Exploring DNA Methylation Diversity in the Honey Bee Brain by Ultra-Deep Amplicon Sequencing.Epigenomes · 2020Article
- Complex impact of DNA methylation on transcriptional dysregulation across 22 human cancer types.Nucleic acids research · 2020Article
- Impacts of Epigenetic Processes on the Health and Productivity of Livestock.Frontiers in genetics · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation is an important epigenetic modification that mediates diverse processes such as cellular differentiation, phenotypic plasticity, and genomic imprinting. Mounting evidence suggests that local DNA sequence variation can be associated with particular DNA methylation states, indicating that the interplay between genetic and epigenetic factors may contribute synergistically to the phenotypic complexity of organisms. Social insects such as ants, bees, and wasps have extensive phenotypic plasticity manifested in their different castes, and this plasticity has been associated with variation in DNA methylation. Yet, the influence of genetic variation on DNA methylation state remains mostly unknown. Here we examine the importance of sequence-specific methylation at the genome-wide level, using whole-genome bisulfite sequencing of the semen of individual honey bee males. We find that individual males harbor unique DNA methylation patterns in their semen, and that genes that are more variable at the epigenetic level are also more likely to be variable at the genetic level. DNA sequence variation can affect DNA methylation by modifying CG sites directly, but can also be associated with local variation in cis that is not CG-site specific. We show that covariation in sequence polymorphism and DNA methylation state contributes to the individual-specificity of epigenetic marks in social insects, which likely promotes their retention across generations, and their capacity to influence evolutionary adaptation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.