Evidence map›Paper›PMID 31406951›Full record

ArticleCurrent opinion in physiology2019

Novel Regulators and Targets of Redox Signaling in Pulmonary Vasculature.

Zdravka Daneva, Victor E Laubach, Swapnil K Sonkusare

Open access · greenAbstract read
In one paragraph

Article in Current opinion in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Endothelial TRPV4 channels in lung edema and injury.Current topics in membranes · 2022
    Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Zdravka DanevaRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, Charlottesville, VA, 22908, USA.
Victor E LaubachDepartment of Surgery, University of Virginia-School of Medicine, Charlottesville, VA, 22908, USA.
Swapnil K SonkusareRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, Charlottesville, VA, 22908, USA.
University of Virginia · US

Funding

Paracrine TNF signaling impairs endothelial TRPV4 microdomains in obesityR01HL142808 · NHLBI · UNIVERSITY OF VIRGINIA · PI Swapnil K. Sonkusare · 2019 to 2026
$4.4M
Flow-Activated Calcium Signaling Microdomains in Small Pulmonary ArteriesR01HL146914 · NHLBI · UNIVERSITY OF VIRGINIA · PI Swapnil K. Sonkusare · 2019 to 2026
$3.8M
Adenosine A2 Receptors and Imaging of Inflammation in Lung Reperfusion InjuryR01HL130053 · NHLBI · UNIVERSITY OF VIRGINIA · PI KRON, IRVING L., LAUBACH, VICTOR E · 2017 to 2020
$2.6M
Pannexin-1 Signaling in Lung Ischemia-Reperfusion InjuryR01HL133293 · NHLBI · UNIVERSITY OF VIRGINIA · PI LAUBACH, VICTOR E · 2017 to 2020
$2.3M
Endothelial TRPV and Potassium Channels Regulate Vascular FunctionR00HL121484 · NHLBI · UNIVERSITY OF VIRGINIA · PI SONKUSARE, SWAPNIL K. · 2015 to 2017
$746k
A novel TRPV4-eNOS signaling pathway in pulmonary endotheliumR56HL138496 · NHLBI · UNIVERSITY OF VIRGINIA · PI SONKUSARE, SWAPNIL K. · 2017 to 2017
$403k
Endothelial TRPV and Potassium Channels Regulate Vascular FunctionK99HL121484 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SONKUSARE, SWAPNIL K. · 2014 to 2014
$128k
NHLBI NIH HHS K99 HL121484NHLBI NIH HHS R00 HL121484NHLBI NIH HHS R01 HL130053NHLBI NIH HHS R01 HL133293NHLBI NIH HHS R01 HL142808NHLBI NIH HHS R01 HL146914NHLBI NIH HHS R56 HL138496
6 · The paper itself

Abstract

Dysregulated redox signaling in pulmonary vasculature is central to the development of pulmonary arterial hypertension (PAH) and lung injury. Modulators of reactive oxygen species (ROS) production and downstream signaling targets are critical for mediating the physiological or pathological effects of ROS. Understanding the complex interactions between the modulators and signaling targets of ROS is essential for developing novel strategies to prevent or attenuate lung pathologies. In this review, we discuss recent studies on the modulators and targets of ROS in pulmonary endothelial and smooth muscle cells, their cellular effects, and the disease conditions associated with dysregulated redox signaling.

Indexed as

endothelial celllung injurypulmonary hypertensionRedox signalingsmooth muscle cell

Identifiers

PMID31406951
PMCPMC6690609
OpenAlexW2943866570

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.