ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2019
Targeted Drug Delivery in Plants: Enzyme-Responsive Lignin Nanocarriers for the Curative Treatment of the Worldwide Grapevine Trunk Disease Esca.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- An integrated green control strategy for plant viral co-infections: from multivalent vaccine construction to synergistically modified nanodelivery systems.Journal of nanobiotechnology · 2026Article
- Mitigating grapevine esca disease: an innovative integrated management strategy to reduce incidence and severity by enhancing plant physiology and defence mechanisms.BMC plant biology · 2026Article
- Advancements in Agricultural Nanotechnology: An Updated Review.Plants (Basel, Switzerland) · 2025Review
- Research Status of Agricultural Nanotechnology and Its Application in Horticultural Crops.Nanomaterials (Basel, Switzerland) · 2025Review
- pH-Responsive Metal-Organic Framework for Targeted Delivery of Fungicide, Release Behavior, and Sustainable Plant Protection.Molecules (Basel, Switzerland) · 2024Article
- Overcoming Challenges of Lignin Nanoparticles: Expanding Opportunities for Scalable and Multifunctional Nanomaterials.Accounts of chemical research · 2024Article
- Carvacrol Encapsulation in Chitosan-Carboxymethylcellulose-Alginate Nanocarriers for Postharvest Tomato Protection.International journal of molecular sciences · 2024Article
- Identification of propranolol and derivatives that are chemical inhibitors of phosphatidate phosphatase as potential broad-spectrum fungicides.Plant communications · 2024Article
- Advancing sustainable agriculture: a critical review of smart and eco-friendly nanomaterial applications.Journal of nanobiotechnology · 2023Review
- Article
- Recent advances in stimuli-response mechanisms of nano-enabled controlled-release fertilizers and pesticides.Eco-Environment & Health · 2023Review
- Lignins as Promising Renewable Biopolymers and Bioactive Compounds for High-Performance Materials.Polymers · 2023Review
- High value valorization of lignin as environmental benign antimicrobial.Materials today. Bio · 2023Review
- Multifunctional Nanocarriers Based on Chitosan Oligomers and Graphitic Carbon Nitride Assembly.Materials (Basel, Switzerland) · 2022Article
- Graphene quantum dots rescue angiogenic retinopathy via blocking STAT3/Periostin/ERK signaling.Journal of nanobiotechnology · 2022Article
- Lignin-based nano-enabled agriculture: A mini-review.Frontiers in plant science · 2022Review
- Combining an HA + Cu (II) Site-Targeted Copper-Based Product with a Pruning Wound Protection Program to Prevent Infection withPlants (Basel, Switzerland) · 2021Article
- Multifunctional lignin-based nanocomposites and nanohybrids.Green chemistry : an international journal and green chemistry resource : GC · 2021Review
- Unravelling the Hydration Barrier of Lignin Oleate Nanoparticles for Acid- and Base-Catalyzed Functionalization in Dispersion State.Angewandte Chemie (International ed. in English) · 2021Article
- Targeted Drug Delivery for Sustainable Crop Protection: Transport and Stability of Polymeric Nanocarriers in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanocarrier (NC)-mediated drug delivery is widely researched in medicine but to date has not been used in agriculture. The first curative NC-based treatment of the worldwide occurring grapevine trunk disease Esca, with more than 2 billion infected plants causing a loss yearly of $1.5 billion, is presented. To date, only repetitive spraying of fungicides is used to reduce chances of infection. This long-term treatment against Esca uses minimal amounts of fungicide encapsulated in biobased and biodegradable lignin NCs. A single trunk injection of <10 mg fungicide results in curing of an infected plant. Only upon Esca infection, ligninolytic enzymes, secreted by the Esca-associated fungi, degrade the lignin NC to release the fungicide. The specific antifungal activity is confirmed in vitro and in planta (in
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