ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2019
Cytocompatible, Injectable, and Electroconductive Soft Adhesives with Hybrid Covalent/Noncovalent Dynamic Network.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 110 citations in OpenAlex.
- Hydrogel-based neural engineering for skin wound healing.Frontiers in cell and developmental biology · 2026Review
- Emerging Smart and Adaptive Hydrogels for Next-Generation Tissue Engineering.Bioengineering (Basel, Switzerland) · 2025Review
- Boosting hydrogel conductivity via water-dispersible conducting polymers for injectable bioelectronics.Nature communications · 2025Article
- Electrically conductive "SMART" hydrogels for on-demand drug delivery.Asian journal of pharmaceutical sciences · 2025Review
- Programmable Release of Chemotherapeutics from Ferrocene-Based Injectable Hydrogels Slows Melanoma Growth.Advanced healthcare materials · 2024Article
- Dynamic hydrogel-metal-organic framework system promotes bone regeneration in periodontitis through controlled drug delivery.Journal of nanobiotechnology · 2024Article
- GelMA/PEDOT:PSS Composite Conductive Hydrogel-Based Generation and Protection of Cochlear Hair Cells through Multiple Signaling Pathways.Biomolecules · 2024Article
- Biomedical applications of engineered heparin-based materials.Bioactive materials · 2024Review
- Resorbable conductive materials for optimally interfacing medical devices with the living.Frontiers in bioengineering and biotechnology · 2024Review
- Chronological adhesive cardiac patch for synchronous mechanophysiological monitoring and electrocoupling therapy.Nature communications · 2023Article
- Nano-crosslinked dynamic hydrogels for biomedical applications.Materials today. Bio · 2023Review
- Investigation of Electrical and Wearing Properties of Wool Fabric Coated with PEDOT:PSS.Polymers · 2023Article
- An injectable gelatin/sericin hydrogel loaded with human umbilical cord mesenchymal stem cells for the treatment of uterine injury.Bioengineering & translational medicine · 2023Article
- Construction and Ion Transport-Related Applications of the Hydrogel-Based Membrane with 3D Nanochannels.Polymers · 2022Review
- Kneading-Inspired Versatile Design for Biomimetic Skins with a Wide Scope of Customizable Features.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- An injectable, self-healing, electroconductive extracellular matrix-based hydrogel for enhancing tissue repair after traumatic spinal cord injury.Bioactive materials · 2022Article
- Ferromagnetic soft catheter robots for minimally invasive bioprinting.Nature communications · 2021Article
- Conducting polymer-based granular hydrogels for injectable 3D cell scaffolds.Advanced materials technologies · 2021Article
- Conductive Hydrogels with Dynamic Reversible Networks for Biomedical Applications.Advanced healthcare materials · 2021Review
- Ultra-Conformable Ionic Skin with Multi-Modal Sensing, Broad-Spectrum Antimicrobial and Regenerative Capabilities for Smart and Expedited Wound Care.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synthetic conductive biopolymers have gained increasing interest in tissue engineering, as they can provide a chemically defined electroconductive and biomimetic microenvironment for cells. In addition to low cytotoxicity and high biocompatibility, injectability and adhesiveness are important for many biomedical applications but have proven to be very challenging. Recent results show that fascinating material properties can be realized with a bioinspired hybrid network, especially through the synergy between irreversible covalent crosslinking and reversible noncovalent self-assembly. Herein, a polysaccharide-based conductive hydrogel crosslinked through noncovalent and reversible covalent reactions is reported. The hybrid material exhibits rheological properties associated with dynamic networks such as self-healing and stress relaxation. Moreover, through fine-tuning the network dynamics by varying covalent/noncovalent crosslinking content and incorporating electroconductive polymers, the resulting materials exhibit electroconductivity and reliable adhesive strength, at a similar range to that of clinically used fibrin glue. The conductive soft adhesives exhibit high cytocompatibility in 2D/3D cell cultures and can promote myogenic differentiation of myoblast cells. The heparin-containing electroconductive adhesive shows high biocompatibility in immunocompetent mice, both for topical application and as injectable materials. The materials could have utilities in many biomedical applications, especially in the area of cardiovascular diseases and wound dressing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.