Evidence map›Paper›PMID 31406600›Full record

ReviewBMJ global health2019

Clinical emergency care research in low-income and middle-income countries: opportunities and challenges.

Adam R Aluisio, Shahan Waheed, Peter Cameron, Jermey Hess, Shevin T Jacob, Niranjan Kissoon, Adam C Levine, Asad Mian, Shammi Ramlakhan, Hendry R Sawe and 1 more

Erratum issued Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in BMJ global health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06075108 (P-KIDs CARE), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06075108 narecruitingnot on this mapstarted 2024, after this paper: background citation

P-KIDs CARE: An Intervention to Address Health Systems Delays to Care for Injured Children in Tanzania

TypeinterventionalSponsorUniversity of UtahRan2024 to 2028Enrolled284ConditionsAccidental Injuries, Global Child Health, Pediatric Emergency Medicine, Public Health System ResearchArmsP-KIDs CARE
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Barriers and facilitators to providing facility-based emergency care in Addis Ababa, Ethiopia: A mixed methods study.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2025
    Article
  7. Article
  8. Triage systems in low-resource emergency care settings.Bulletin of the World Health Organization · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. [Indicators to measure the performance of emergency trauma care].Revista medica del Instituto Mexicano del Seguro Social · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Navigating ethical challenges of conducting randomized clinical trials on COVID-19.Philosophy, ethics, and humanities in medicine : PEHM · 2022
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 7 countries.

Adam R AluisioDepartment of Emergency Medicine, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA.ORCID 0000-0001-7329-7333
Shahan WaheedDepartment of Emergency Medicine, Aga Khan University Hospital, Karachi, Pakistan.
Peter CameronDepartment of Epidemiology and Preventive Medicine, Monash University, Clayton, Victoria, Australia.
Jermey HessDepartment of Emergency Medicine, School of Public Health, University of Washington, Seattle, Washington, USA.
Shevin T JacobDivision of Allergy and Infectious Diseases, Universityof Washington, Seattlel, WA, United States.
Niranjan KissoonDepartmentof Pediatrics and Emergency Medicine, School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Adam C LevineDepartment of Emergency Medicine, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Asad MianDepartment of Emergency Medicine, Aga Khan University Hospital, Karachi, Pakistan.
Shammi RamlakhanEmergency Department, Sheffield Children's Hospital, Sheffield, UK.
Hendry R SaweEmergency Medicine Department, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.ORCID 0000-0002-0395-5385
Junaid RazzakDepartment of Emergency Medicine, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Aga Khan University Hospital · PKBrown University · USUniversity of Washington · USJohns Hopkins University · USMonash University · AUMuhimbili University of Health and Allied Sciences · TZUniversity of British Columbia · CAUniversity of the West Indies · JM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disease processes that frequently require emergency care constitute approximately 50% of the total disease burden in low-income and middle-income countries (LMICs). Many LMICs continue to deal with emergencies caused by communicable disease states such as pneumonia, diarrhoea, malaria and meningitis, while also experiencing a marked increase in non-communicable diseases, such as cardiovascular diseases, diabetes mellitus and trauma. For many of these states, emergency care interventions have been developed through research in high-income countries (HICs) and advances in care have been achieved. However, in LMICs, clinical research, especially interventional trials, in emergency care are rare. Furthermore, there exists minimal research on the emergency management of diseases, which are rarely encountered in HICs but impact the majority of LMIC populations. This paper explores challenges in conducting clinical research in patients with emergency conditions in LMICs, identifies examples of successful clinical research and highlights the system, individual and study design characteristics that made such research possible in LMICs. Derived from the available literature, a focused list of high impact research considerations are put forth.

Indexed as

diseasesdisordersinjuriespublic healthstudy design

Identifiers

PMID31406600
PMCPMC6666826
OpenAlexW2965931930

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.