Evidence map›Paper›PMID 31406598›Full record

ReviewBMJ global health2019

Emergency care research ethics in low-income and middle-income countries.

Joseph Millum, Blythe Beecroft, Timothy Craig Hardcastle, Jon Mark Hirshon, Adnan A Hyder, Jennifer A Newberry, Carla Saenz

Registry-linked trialAbstract readReview
In one paragraph

Review in BMJ global health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06075108 (P-KIDs CARE), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06075108 narecruitingnot on this mapstarted 2024, after this paper: background citation

P-KIDs CARE: An Intervention to Address Health Systems Delays to Care for Injured Children in Tanzania

TypeinterventionalSponsorUniversity of UtahRan2024 to 2028Enrolled284ConditionsAccidental Injuries, Global Child Health, Pediatric Emergency Medicine, Public Health System ResearchArmsP-KIDs CARE
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. A Characterization of Pediatric Burn Injury Patients Presenting to a Zonal Referral Hospital in Northern Tanzania.Journal of burn care & research : official publication of the American Burn Association · 2026
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joseph MillumDepartment of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0716-9880
Blythe BeecroftFogarty International Center, National Institutes of Health, Bethesda, MD, USA.
Timothy Craig HardcastleNelson R Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.
Jon Mark HirshonUniversity of Maryland School of Medicine, University of Maryland, Baltimore, MD, United States.
Adnan A HyderMilken Institute School of Public Health, George Washington University, Washington, DC, USA.
Jennifer A NewberryStanford University School of Medicine, Stanford University, Stanford, CA, USA.
Carla SaenzRegional Program on Bioethics, Department of Health Systems and Services, Pan American Health Organization, Washington, DC, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A large proportion of the total global burden of disease is caused by emergency medical conditions. Emergency care research is essential to improving emergency medicine but this research can raise some distinctive ethical challenges, especially with regard to (1) standard of care and risk-benefit assessment; (2) blurring of the roles of clinician and researcher; (3) enrolment of populations with intersecting vulnerabilities; (4) fair participant selection; (5) quality of consent; and (6) community engagement. Despite the importance of research to improve emergency care in low-income and middle-income countries (LMICs) and the widely acknowledged ethical challenges, very little has been written on the ethics of emergency care research in LMICs. This paper examines the ethical and regulatory challenges to conducting emergency care research with human participants in LMICs. We outline key challenges, present potential solutions or frameworks for addressing these challenges, and identify gaps. Despite the ethical and regulatory challenges, conducting high-quality, ethical emergency care research in LMICs is possible and it is essential for global health.

Indexed as

emergency careethical emergency care researchresearch ethics

Identifiers

PMID31406598
PMCPMC6666811

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.