Evidence map›Paper›PMID 31406505›Full record

ReviewJournal of biological engineering2019

The LINC complex, mechanotransduction, and mesenchymal stem cell function and fate.

Tasneem Bouzid, Eunju Kim, Brandon D Riehl, Amir Monemian Esfahani, Jordan Rosenbohm, Ruiguo Yang, Bin Duan, Jung Yul Lim

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of biological engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 163 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Sono-Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. The Nemp1-Nesprin complex mediates cellular responses to matrix mechanics.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Mechanoepigenetics in musculoskeletal disease.Osteoarthritis and cartilage · 2026
    Review
  12. Review
  13. Article
  14. Mechanobiological Dynamics-Inspired Mechanomodulatory Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  15. Review
  16. Article
  17. Review
  18. Lamin A/C as a biomarker for breast cancer.Molecular biology reports · 2025
    Review
  19. Article
  20. Article

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tasneem Bouzid1Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, W317.3 Nebraska Hall, Lincoln, NE 68588 USA.
Eunju Kim1Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, W317.3 Nebraska Hall, Lincoln, NE 68588 USA.
Brandon D Riehl1Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, W317.3 Nebraska Hall, Lincoln, NE 68588 USA.
Amir Monemian Esfahani1Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, W317.3 Nebraska Hall, Lincoln, NE 68588 USA.
Jordan Rosenbohm1Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, W317.3 Nebraska Hall, Lincoln, NE 68588 USA.
Ruiguo Yang1Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, W317.3 Nebraska Hall, Lincoln, NE 68588 USA.
Bin Duan1Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, W317.3 Nebraska Hall, Lincoln, NE 68588 USA.
Jung Yul Lim1Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, W317.3 Nebraska Hall, Lincoln, NE 68588 USA.ORCID 0000-0002-9409-7522
University of Nebraska–Lincoln · US

Funding

Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GUDA, CHITTIBABU · 2016 to 2025
$42.8M
The role of stress in the fetal origin of obesity and metabolic dysfunctionP20GM104320 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI ZEMPLENI, JANOS · 2014 to 2024
$24.9M
NIGMS NIH HHS P20 GM104320NIGMS NIH HHS U54 GM115458
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) show tremendous promise as a cell source for tissue engineering and regenerative medicine, and are understood to be mechanosensitive to external mechanical environments. In recent years, increasing evidence points to nuclear envelope proteins as a key player in sensing and relaying mechanical signals in MSCs to modulate cellular form, function, and differentiation. Of particular interest is the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex that includes nesprin and SUN. In this review, the way in which cells can sense external mechanical environments through an intact nuclear envelope and LINC complex proteins will be briefly described. Then, we will highlight the current body of literature on the role of the LINC complex in regulating MSC function and fate decision, without and with external mechanical loading conditions. Our review and suggested future perspective may provide a new insight into the understanding of MSC mechanobiology and related functional tissue engineering applications.

Indexed as

Functional tissue engineeringLinker of Nucleoskeleton and cytoskeleton (LINC)MechanotransductionMesenchymal stem cellsNesprinSUN

Identifiers

PMID31406505
PMCPMC6686368
OpenAlexW2965783660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.