Evidence map›Paper›PMID 31406486›Full record

ArticleCancer cell international2019

LINC00309 is associated with short disease-free survival in breast cancer.

Sheng Huang, Yayun Chi, Weiru Chi, Rong Guo, Yonghui Su, Jingyan Xue, Shaoqiang Zhou, Jiankui Wang, Zhuangqing Yang, Jianyun Nie and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Sheng Huang *1Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Building 2, No. 270 Dong An Road, Shanghai, 200032 China.
Yayun Chi *1Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Building 2, No. 270 Dong An Road, Shanghai, 200032 China.
Weiru Chi *1Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Building 2, No. 270 Dong An Road, Shanghai, 200032 China.
Rong Guo1Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Building 2, No. 270 Dong An Road, Shanghai, 200032 China.
Yonghui Su1Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Building 2, No. 270 Dong An Road, Shanghai, 200032 China.
Jingyan Xue1Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Building 2, No. 270 Dong An Road, Shanghai, 200032 China.
Shaoqiang ZhouThe 2nd Department of Breast Surgery, Breast Cancer Center of the Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Building 3, No. 519 Kunzhou Road, Kunming, 650118 China.
Jiankui WangThe 2nd Department of Breast Surgery, Breast Cancer Center of the Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Building 3, No. 519 Kunzhou Road, Kunming, 650118 China.
Zhuangqing YangThe 2nd Department of Breast Surgery, Breast Cancer Center of the Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Building 3, No. 519 Kunzhou Road, Kunming, 650118 China.
Jianyun NieThe 2nd Department of Breast Surgery, Breast Cancer Center of the Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Building 3, No. 519 Kunzhou Road, Kunming, 650118 China.
Zhimin Shao1Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Building 2, No. 270 Dong An Road, Shanghai, 200032 China.
Dedian ChenThe 2nd Department of Breast Surgery, Breast Cancer Center of the Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Building 3, No. 519 Kunzhou Road, Kunming, 650118 China.
Jiong Wu1Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Building 2, No. 270 Dong An Road, Shanghai, 200032 China.ORCID 0000-0002-8155-9126
Shanghai Medical College of Fudan University · CNKunming Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLong non-coding RNAs play an important role in breast cancer. Even with adjuvant hormone therapy, patients with estrogen receptor positive breast cancer can present with recurrences and distant metastases. We investigated whether the expression of a novel long non-coding RNA LINC00309 can predict the outcome of breast cancer, especially for hormone-receptor positive patients.

methodsThis retrospective study collected 290 breast cancer patients including 161 patients with hormone-positive. qPCR was performed to detect the expression of LINC00309. Kaplan-Meier and Cox risk proportion model were applied to disclose the function of LINC00309 for breast cancer prognosis.

resultsLINC00309 high expression was an independent predictor for worse disease-free survival (

conclusionIn breast cancer, Linc00309 is significantly associated with poor prognosis and may represent a new marker of prognosis.

Indexed as

Breast cancerEndocrine therapy resistanceLINC00309Long non-coding RNA

Identifiers

PMID31406486
PMCPMC6686222
OpenAlexW2964973351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.