ArticleNature chemical biology2019
A synthetic system for asymmetric cell division in Escherichia coli.
Article in Nature chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
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- Construction and phenotypic classification of synthetic dual-pole Escherichia coli cells.Communications biology · 2025Article
- Harnessing microbial heterogeneity for improved biosynthesis fueled by synthetic biology.Synthetic and systems biotechnology · 2025Review
- Light-dependent modulation of protein localization and function in living bacteria cells.Nature communications · 2024Article
- Tunable cell differentiation via reprogrammed mating-type switching.Nature communications · 2024Article
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- Engineering synthetic biomolecular condensates.Nature reviews bioengineering · 2023Review
- Programmable synthetic biomolecular condensates for cellular control.Nature chemical biology · 2023Article
- You're in then you're out.Nature chemical biology · 2023Article
- Construction of intracellular asymmetry and asymmetric division in Escherichia coli.Nature communications · 2021Article
- Functional roles of microbial cell-to-cell heterogeneity and emerging technologies for analysis and control.Current opinion in microbiology · 2020Review
- Proceedings of the 7th ACM International Conference on Nanoscale Computing and Communication : Virtual Conference, September 23-25, 2020 : NanoCom 2020. ACM International Conference on Nanoscale Computing and Communication (7th : 2020 :... · 2020Article
- Bacterial chromosome segregation by the ParABS system.Open biology · 2020Review
- Differentiating bacteria.Nature reviews. Microbiology · 2019Article
- Synthetic bacterial stem cells and their multicellularity for synthetic biology and beyond.Synthetic biology (Oxford, England) · 2019Article
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6 authors at 2 institutions in 1 country.
Funding
Abstract
We describe a synthetic genetic circuit for controlling asymmetric cell division in Escherichia coli in which a progenitor cell creates a differentiated daughter cell while retaining its original phenotype. Specifically, we engineered an inducible system that can bind and segregate plasmid DNA to a single position in the cell. Upon cell division, colocalized plasmids are kept by one and only one of the daughter cells. The other daughter cell receives no plasmid DNA and is irreversibly differentiated from its sibling. In this way, we achieved asymmetric cell division through asymmetric plasmid partitioning. We then used this system to achieve physical separation of genetically distinct cells by tying motility to differentiation. Finally, we characterized an orthogonal inducible circuit that enables the simultaneous asymmetric partitioning of two plasmid species, resulting in cells that have four distinct differentiated states. These results point the way toward the engineering of multicellular systems from prokaryotic hosts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.