ReviewNature biotechnology2019
Next-generation interfaces for studying neural function.
Review in Nature biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed.
- Minimally invasive bioelectronic implants.Nature materials · 2026Review
- Design, Construction, and Application of Implantable Fiber Biosensors.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- A Dual-Mode Neural Amplifier Array for Biopotential and FSCV-Based Neurochemical Measurements.Biosensors · 2026Article
- Article
- Technology roadmap from fiber materials to fiber electronics.National science review · 2026Review
- Tissue-adhesive hydrogel optical fiber for peripheral optogenetic neuromodulation.Nature communications · 2026Article
- PolyGraph - Flexible, Biocompatible & Electrically Optimized Graphene-Polymer Composites for Next-Generation Neural Interfaces.Advanced healthcare materials · 2026Article
- Tissue-adaptive bioelectronic fibers with temperature-induced self-tightening enable ultrastable neural interface.Nature communications · 2026Article
- Transparent Transfer-Free Ultrasmall Multilayer Graphene Microelectrodes Enable High Quality Recordings in Brain Slices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Electrically Tunable Optofluidic Metasurface.ACS nano · 2026Article
- Interrogating functional connectivity of in vitro neural glia tissue model modulated through integrative control of matrix stiffness and a neurotrophic factor.Biomaterials · 2026Article
- Bridging the translational gap in systems neuroscience: from circuit mechanisms to clinical therapeutics.Frontiers in pharmacology · 2026Review
- Neural stem cell-loaded biohybrid hydrogel improves cochlear implants by electrode-neural coupling and neural regeneration.Theranostics · 2026Article
- Experimental investigation of sharp-tip microwire-based brain electrode buckling during implantation through dura and pia mater.Frontiers in neuroscience · 2026Article
- Performance-Recoverable Closed-Loop Neuroprosthetic System.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- An Implantable, Ultralow Distortion Bioelectronic Interface Integrating Light-Emitting Diodes and Graphene Field-Effect Transistors.ACS nano · 2025Article
- A bioelectric router for adaptive isochronous neurostimulation enables multipolar bioelectric stimulation from a single source.Scientific reports · 2025Article
- Multifunctional bioelectronics for brain-body circuits.Nature reviews bioengineering · 2025Article
- Materials and device strategies to enhance spatiotemporal resolution in bioelectronics.Nature reviews. Materials · 2025Article
- Miniaturized Iontronic Micropipettes for Precise and Dynamic Ionic Modulation of Neuronal and Astrocytic Activity.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Monitoring and modulating the diversity of signals used by neurons and glia in a closed-loop fashion is necessary to establish causative links between biochemical processes within the nervous system and observed behaviors. As developments in neural-interface hardware strive to keep pace with rapid progress in genetically encoded and synthetic reporters and modulators of neural activity, the integration of multiple functional features becomes a key requirement and a pressing challenge in the field of neural engineering. Electrical, optical and chemical approaches have been used to manipulate and record neuronal activity in vivo, with a recent focus on technologies that both integrate multiple modes of interaction with neurons into a single device and enable bidirectional communication with neural circuits with enhanced spatiotemporal precision. These technologies not only are facilitating a greater understanding of the brain, spinal cord and peripheral circuits in the context of health and disease, but also are informing the development of future closed-loop therapies for neurological, neuro-immune and neuroendocrine conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.