Trial reportBritish journal of cancer2019
Signet ring cell colorectal cancer: genomic insights into a rare subpopulation of colorectal adenocarcinoma.
Trial report in British journal of cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- The Molecular Associations of Signet-Ring Cell Carcinoma in Colorectum: Meta-Analysis and System Review.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Young-onset signet ring cell colorectal adenocarcinoma: demographics, clinicopathological profile, and survival analysis.Proceedings (Baylor University. Medical Center) · 2026Article
- Distinct genomic landscape of colorectal signet ring cell carcinoma reveals frequent KMT2 family alterations and SMAD4 inactivation.BMC cancer · 2026Article
- Primary colonic signet-ring cell carcinoma in an elderly patient: a rare case report.International journal of surgery case reports · 2026Article
- Prognostic value of PLN, LNR, and LODDS in advanced colorectal signet ring cell carcinoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Signet-Ring Cell Colorectal Cancer and Signet-Ring Cell Component Colorectal Cancer: Do They Differ in Clinical Behavior?Journal of clinical medicine · 2026Article
- Clinicopathologic, genetic and immune cell infiltration analysis of colorectal signet ring cell carcinoma with comparison to conventional adenocarcinoma.Journal of the National Cancer Center · 2026Article
- Primary Colorectal Signet Ring Cell Carcinoma and the Risk of Multiple Primary Gastrointestinal Malignancies: A Retrospective Cohort Based on SEER Database from 2000-2021.Clinical and experimental gastroenterology · 2026Article
- Clinicopathological Features and Prognostic Impact of Colorectal Signet-Ring Cell Carcinoma: The Prognostic Impact of Metastatic Lymph Node Histology.Journal of the anus, rectum and colon · 2026Article
- Primary Colorectal Signet-Ring Cell Carcinoma with Synchronous Colonic Metastases in an Asymptomatic Patient: Case Presentation and Comprehensive Literature Review.Life (Basel, Switzerland) · 2025Article
- Cancer-associated adipocytes promote peritoneal metastasis of colorectal signet ring cell carcinoma via FABP4 induction.Cell communication and signaling : CCS · 2025Article
- Association ofJCO precision oncology · 2025Article
- Acellular mucin in neoplastic and non-neoplastic conditions of the lower gastrointestinal tract.World journal of gastrointestinal surgery · 2025Review
- Deep visual proteomics reveals DNA replication stress as a hallmark of signet ring cell carcinoma.NPJ precision oncology · 2025Article
- Prognostic value of positive lymph node ratio, tumor deposit, and perineural invasion in advanced colorectal signet-ring cell carcinoma.Frontiers in molecular biosciences · 2025Article
- Prognostic value of preoperative and postoperative serum CEA in colorectal signet ring cell carcinoma.Frontiers in surgery · 2025Article
- A predictive and prognostic model for metastasis risk and prognostic factors in gastrointestinal signet ring cell carcinoma.European journal of medical research · 2024Article
- Molecular characteristics of patients with colorectal signet-ring cell carcinoma with different ABO blood groups.Heliyon · 2024Article
- Inherited KDM6AOncogene · 2024Article
- Systematic review of risk factors, prognosis, and management of colorectal signet-ring cell carcinoma.World journal of gastrointestinal oncology · 2024Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundSignet ring cell carcinoma (SRCC) is a rare subtype of colorectal cancer (CRC). The aim of this study was to characterise the genomic alterations and outcomes of SRCC.
methodsMedical records of metastatic CRC (mCRC) patients whose tumours were evaluated by NGS analysis were reviewed. SC-mCRC were classified into two groups: SRCC (>50% signet ring cells) and adenocarcinoma (AC) with SC component (≤50% signet ring cells).
resultsSix hundred and sixty-five mCRC patients were included. Of the 93 mCRC cases with SC features, 63 had slides for review. Of those 63 cases, 35 were confirmed SRCC, and 28 were AC with SC component. Compared with AC group, KRAS and PIK3CA mutations (mts) were found in only 11% (OR: 0.13) and 3% (OR: 0.15) of SRCC cases, respectively. In contrast to the 44% rate of APC mts in AC group, only 3% of SRCC patients had APC mts (OR = 0.04).
conclusionsSRCC has distinct molecular features, including low rates of KRAS, PIK3CA and APC mts. Further study to identify activation pathways and potential therapeutic targets are needed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.