Evidence map›Paper›PMID 31406255›Full record

ArticleOncogene2019

BRAF

Daofu Feng, Bo Qin, Krishnendu Pal, Lei Sun, Shamit Dutta, Haidong Dong, Xin Liu, Debabrata Mukhopadhyay, Shengbing Huang, Frank A Sinicrope

Abstract read
In one paragraph

Article in Oncogene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Review
  8. Preclinical assessment of genetically modified exosomes for colorectal cancer immunotherapy.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Article
  9. Analysis of PD-L1 Transcriptional Activity by Chromatin Immunoprecipitation.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Immune Marker Spatial Distribution and Clinical Outcome after PD-1 Blockade in Mismatch Repair-deficient, Advanced Colorectal Carcinomas.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daofu FengGastrointestinal Research Unit, Rochester, MN, 55905, USA.
Bo QinGastrointestinal Research Unit, Rochester, MN, 55905, USA.
Krishnendu PalDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Jacksonville, FL, 32224, USA.
Lei SunGastrointestinal Research Unit, Rochester, MN, 55905, USA.
Shamit DuttaDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Jacksonville, FL, 32224, USA.
Haidong DongDepartment of Immunology, Mayo Clinic, Rochester, MN, 55905, USA.
Xin LiuDepartment of Immunology, Mayo Clinic, Rochester, MN, 55905, USA.
Debabrata MukhopadhyayDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Jacksonville, FL, 32224, USA.
Shengbing HuangGastrointestinal Research Unit, Rochester, MN, 55905, USA.
Frank A SinicropeGastrointestinal Research Unit, Rochester, MN, 55905, USA. sinicrope.frank@mayo.edu.

Funding

Integration of Genomic and Clinical Data to Enhance Subtyping of Colon CancerR01CA210509 · NCI · MAYO CLINIC ROCHESTER · PI SINICROPE, FRANK A. · 2017 to 2021
$2.0M
NCI NIH HHS R01 CA210509
6 · The paper itself

Abstract

Programmed death ligand 1 (PD-L1) is an immune checkpoint protein; however, emerging data suggest that tumor cell PD-L1 may regulate immune-independent and intrinsic cellular functions. We demonstrate regulation of PD-L1 by oncogenic BRAF

Indexed as

AnimalsAntineoplastic AgentsApoptosisB7-H1 AntigenCell Line, TumorColorectal NeoplasmsGene Knockdown TechniquesHumansMiceProto-Oncogene Proteins B-rafUp-RegulationXenograft Model Antitumor AssaysAntineoplastic AgentsB7-H1 AntigenBRAF protein, humanCD274 protein, humanProto-Oncogene Proteins B-raf

Identifiers

PMID31406255
PMCPMC6786951

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.