Evidence map›Paper›PMID 31406197›Full record

ArticleScientific reports2019

Contrast sensitivity isocontours of the central visual field.

Agnes Y J Choi, Lisa Nivison-Smith, Jack Phu, Barbara Zangerl, Sieu K Khuu, Bryan W Jones, Rebecca L Pfeiffer, Robert E Marc, Michael Kalloniatis

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Characterisation of the normal human ganglion cell-inner plexiform layer using widefield optical coherence tomography.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2024
    Article
  4. Article
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  6. Prediction of visual field defects from macular optical coherence tomography in glaucoma using cluster analysis.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Agnes Y J ChoiCentre for Eye Health, The University of New South Wales, Kensington, New South Wales, Australia.
Lisa Nivison-SmithCentre for Eye Health, The University of New South Wales, Kensington, New South Wales, Australia.ORCID http://orcid.org/0000-0001-6677-1949
Jack PhuCentre for Eye Health, The University of New South Wales, Kensington, New South Wales, Australia.ORCID http://orcid.org/0000-0002-9933-6780
Barbara ZangerlCentre for Eye Health, The University of New South Wales, Kensington, New South Wales, Australia.
Sieu K KhuuSchool of Optometry and Vision Science, The University of New South Wales, Kensington, New South Wales, Australia.
Bryan W JonesDepartment of Ophthalmology, Moran Eye Center, University of Utah, Salt Lake City, Utah, United States.
Rebecca L PfeifferDepartment of Ophthalmology, Moran Eye Center, University of Utah, Salt Lake City, Utah, United States.ORCID http://orcid.org/0000-0002-4123-516X
Robert E MarcDepartment of Ophthalmology, Moran Eye Center, University of Utah, Salt Lake City, Utah, United States.
Michael KalloniatisCentre for Eye Health, The University of New South Wales, Kensington, New South Wales, Australia. m.kalloniatis@unsw.edu.au.

Funding

University of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI PAUL STEVEN BERNSTEIN · 2005 to 2026
$14.6M
STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITSR01EY002576 · NEI · UNIVERSITY OF UTAH · PI MARC, ROBERT E · 1985 to 2016
$8.0M
Retinal RemodelingR01EY015128 · NEI · UNIVERSITY OF UTAH · PI JONES, BRYAN WILLIAM · 2004 to 2021
$7.0M
Retinal CircuitryR01EY028927 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Bryan William Jones · 2019 to 2026
$5.2M
Vision Research Training Grant at the University of UtahT32EY024234 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI DAVID KRIZAJ, Monica L Vetter · 2014 to 2026
$2.3M
NEI NIH HHS P30 EY014800NEI NIH HHS R01 EY002576NEI NIH HHS R01 EY015128NEI NIH HHS R01 EY028927NEI NIH HHS T32 EY024234
6 · The paper itself

Abstract

Standard automated perimetry (SAP), the most common form of perimetry used in clinical practice, is associated with high test variability, impacting clinical decision making and efficiency. Contrast sensitivity isocontours (CSIs) may reduce test variability in SAP by identifying regions of the visual field with statistically similar patterns of change that can be analysed collectively and allow a point (disease)-to-CSI (normal) comparison in disease assessment as opposed to a point (disease)-to-point (normal) comparison. CSIs in the central visual field however have limited applicability as they have only been described using visual field test patterns with low, 6° spatial sampling. In this study, CSIs were determined within the central 20° visual field using the 10-2 test grid paradigm of the Humphrey Field Analyzer which has a high 2° sampling frequency. The number of CSIs detected in the central 20° visual field was greater than previously reported with low spatial sampling and stimulus size dependent: 6 CSIs for GI, 4 CSIs for GII and GIII, and 3 CSIs for GIV and GV. CSI number and distribution were preserved with age. Use of CSIs to assess visual function in age-related macular degeneration (AMD) found CSI guided analysis detected a significantly greater deviation in sensitivity of AMD eyes from normal compared to a standard clinical pointwise comparison (-1.40 ± 0.15 dB vs -0.96 ± 0.15 dB; p < 0.05). This work suggests detection of CSIs within the central 20° is dependent on sampling strategy and stimulus size and normative distribution limits of CSIs can indicate significant functional deficits in diseases affecting the central visual field such as AMD.

Indexed as

Contrast SensitivityVisual FieldsAdultAgedCluster AnalysisFemaleHumansMacular DegenerationMaleMiddle AgedVisual Field TestsYoung Adult

Identifiers

PMID31406197
PMCPMC6691009

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.