ArticleScientific reports2019
The Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 2017.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Pooled it
- Cardiac injury in children with severe hand, foot and mouth disease: risk factors and clinical outcomes.Infection · 2026Article
- Review
- Molecular epidemiology and clinical features of hand, foot and mouth disease requiring hospitalization after the use of enterovirus A71 inactivated vaccine in chengdu, China, 2017-2022: a descriptive study.Emerging microbes & infections · 2022Article
- Molecular epidemiology of enteroviruses associated with hand, foot, and mouth disease in South India from 2015 to 2017.Archives of virology · 2022Article
- Enterovirus A71 antivirals: Past, present, and future.Acta pharmaceutica Sinica. B · 2022Article
- Assessment of liver fibrosis by transient elastography and multi-parameters model in young children with chronic hepatitis B virus infection.BMC infectious diseases · 2022Article
- Analysis of miRNAs Involved in Mouse Heart Injury Upon Coxsackievirus A2 Infection.Frontiers in cellular and infection microbiology · 2022Article
- Molecular epidemiology of coxsackievirus A16 circulating in children in Beijing, China from 2010 to 2019.World journal of pediatrics : WJP · 2021Article
- A five-year retrospective study on the epidemiology of hand, foot and mouth disease in Sabah, Malaysia.Scientific reports · 2021Article
- Molecular Epidemiological Study of Hand, Foot, and Mouth Disease in a Kindergarten-Based Setting in Bangkok, Thailand.Pathogens (Basel, Switzerland) · 2021Article
- Regional-level risk factors for severe hand-foot-and-mouth disease: an ecological study from mainland China.Environmental health and preventive medicine · 2021Article
- Molecular Epidemiology and Clinical Features of Enteroviruses-Associated Hand, Foot, and Mouth Disease and Herpangina Outbreak in Zunyi, China, 2019.Frontiers in medicine · 2021Article
- Forecasting hand-foot-and-mouth disease cases using wavelet-based SARIMA-NNAR hybrid model.PloS one · 2021Article
- Association of environmental factors and high HFMD occurrence in northern Thailand.BMC public health · 2020Article
- Epidemiological and clinical characteristics of severe hand-foot-and-mouth disease (HFMD) among children: a 6-year population-based study.BMC public health · 2020Article
- Incidence of Infection of Enterovirus 71 and Coxsackieviruses A6 and A16 among Household Contacts of Index Cases in Dong Thap Province, Southern Vietnam.BioMed research international · 2020Article
- Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Predicting Death Risk in Patients with Severe Hand, Foot and Mouth Disease.Therapeutics and clinical risk management · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hand, foot, and mouth disease (HFMD) is endemic in the Pacific region, especially in mainland China. The case-fatality ratio of HFMD is increasing steadily. Knowledge of the changing epidemiology of HFMD in different regions is necessary for implementing appropriate intervention strategies. In this study, we describe the clinical and epidemiological characteristics of HFMD in Hunan Children's Hospital between 2013 and 2017. A total of 7203 patients with HFMD were admitted, with complication and mortality rates of 35.62% and 0.78%, respectively. The total number of children with HFMD, proportion of severely ill children, and HFMD mortality rate were the highest in 2014. The number of cases caused by EV-A71 and CV-A16 decreased continuously, while the number of cases caused by 'other enteroviruses' increased yearly since 2014, suggesting that other enteric viruses will gradually replace EV-A71 and CV-A16 as the main pathogenic HFMD agents. Furthermore, EV-A71 and mixed infections accounted for the high case fatality rates in children with severe HFMD, among whom EV-A71 infection resulted in the highest complication and mortality rates; the mild form of the disease was dominated by 'other enteroviruses'. In conclusion, the changing etiological pattern highlights the need to improve pathogen surveillance and vaccine strategies for HFMD control.
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