Evidence map›Paper›PMID 31406125›Full record

ArticleScientific reports2019

Genomic approaches to identify hybrids and estimate admixture times in European wildcat populations.

Federica Mattucci, Marco Galaverni, Leslie A Lyons, Paulo C Alves, Ettore Randi, Edoardo Velli, Luca Pagani, Romolo Caniglia

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
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  8. Article
  9. Phylogenetic History and Phylogeographic Patterns of the European Wildcat (Animals : an open access journal from MDPI · 2023
    Article
  10. Article
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  13. "Guess Who's Coming to Dinner": Molecular Tools to ReconstructAnimals : an open access journal from MDPI · 2022
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  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Hybridization betweenEcology and evolution · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 5 countries.

Federica MattucciArea per la Genetica della Conservazione (BIO-CGE), Istituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA), Ozzano dell'Emilia, Italy. federica.mattucci@isprambiente.it.
Marco GalaverniArea Conservazione, WWF Italia, Rome, Italy.
Leslie A LyonsDepartment of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, USA.
Paulo C AlvesCentro de Investigação em Biodiversidade e Recursos Genéticos (CIBIO), InBio - Laboratório Associado, Campus Agrário de Vairão, Vairão, Portugal.ORCID http://orcid.org/0000-0003-4797-0939
Ettore RandiDepartment of Biological, Geological and Environmental Sciences, University of Bologna, Bologna, Italy.
Edoardo VelliArea per la Genetica della Conservazione (BIO-CGE), Istituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA), Ozzano dell'Emilia, Italy.
Luca PaganiDipartimento di Biologia, Università degli Studi di Padova, Padua, Italy.
Romolo CanigliaArea per la Genetica della Conservazione (BIO-CGE), Istituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA), Ozzano dell'Emilia, Italy.
Istituto Superiore per la Protezione e la Ricerca Ambientale · ITAalborg University · DKMissouri College · USUniversidade do Porto · PTUniversity of Padua · ITWWF Italia · IT

Funding

HSRD VA CDA 10-014
6 · The paper itself

Abstract

The survival of indigenous European wildcat (Felis silvestris silvestris) populations can be locally threatened by introgressive hybridization with free-ranging domestic cats. Identifying pure wildcats and investigating the ancestry of admixed individuals becomes thus a conservation priority. We analyzed 63k cat Single Nucleotide Polymorphisms (SNPs) with multivariate, Bayesian and gene-search tools to better evaluate admixture levels between domestic and wild cats collected in Europe, timing and ancestry proportions of their hybrids and backcrosses, and track the origin (wild or domestic) of the genomic blocks carried by admixed cats, also looking for possible deviations from neutrality in their inheritance patterns. Small domestic ancestry blocks were detected in the genomes of most admixed cats, which likely originated from hybridization events occurring from 6 to 22 generations in the past. We identified about 1,900 outlier coding genes with excess of wild or domestic ancestry compared to random expectations in the admixed individuals. More than 600 outlier genes were significantly enriched for Gene Ontology (GO) categories mainly related to social behavior, functional and metabolic adaptive processes (wild-like genes), involved in cognition and neural crest development (domestic-like genes), or associated with immune system functions and lipid metabolism (parental-like genes). These kinds of genomic ancestry analyses could be reliably applied to unravel the admixture dynamics in European wildcats, as well as in other hybridizing populations, in order to design more efficient conservation plans.

Indexed as

GenomicsHybridization, GeneticAnimalsAnimals, WildCatsConservation of Natural ResourcesDNA, MitochondrialEuropeMutationPolymorphism, Single NucleotideDNA, Mitochondrial

Identifiers

PMID31406125
PMCPMC6691104
OpenAlexW2967480679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.