ReviewProceedings of the Japan Academy. Series B, Physical and biological sciences2019
The basic repeating modules of the cerebral cortical circuit.
Review in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Macroscopic quantum effects in the brain: new insights into the fundamental principle underlying conscious processes.Frontiers in human neuroscience · 2025Article
- Review
- Laying the foundations for a theory of consciousness: the significance of critical brain dynamics for the formation of conscious states.Frontiers in human neuroscience · 2024Article
- Three distinct gamma oscillatory networks within cortical columns in macaque monkeys' area V1.Frontiers in neural circuits · 2024Article
- Tuning Criticality through Modularity in Biological Neural Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Structural Modularity Tunes Mesoscale Criticality in Biological Neuronal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity.Frontiers in neuroanatomy · 2022Article
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Abstract
The fundamental organization of the cerebral cortical circuit is still poorly understood. In particular, it is unclear whether the diverse cell types form modular units that are repeated across the cortex. We discovered that the major cell types in cortical layer 5 form a lattice structure. Distinct types of excitatory and inhibitory neurons form cell type-specific radial clusters termed microcolumns. Microcolumns are present in diverse cortical areas, such as the visual, motor, and language areas, and are organized into periodic hexagonal lattice structures. Individual microcolumns have modular synaptic circuits and exhibit modular neuronal activity, suggesting that each of them functions as an information processing unit. Microcolumn development is suggested to be independent of cell lineage but coordinated by gap junctions. Thus, neurons in cortical layer 5 organize into a brainwide lattice structure of functional microcolumns, suggesting that parallel processing by massively repeated microcolumns underlie diverse cortical functions, such as sensory perception, motor control, and language processing.
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