ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Connectomic Identification and Three-Dimensional Color Tuning of S-OFF Midget Ganglion Cells in the Primate Retina.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Synaptic Organization of the Primate Retina: Toward a Human Foveal Connectome.Annual review of vision science · 2026Review
- Approaching a connectome of the human foveal retina.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Filter, Detector, Predictor: The expanding repertoire of retinal computation in vertebrates.Vision research · 2026Review
- Connectome of a human foveal retina.bioRxiv : the preprint server for biology · 2026Article
- Decoding the roles of bipolar, amacrine, and horizontal cells.Handbook of clinical neurology · 2026Review
- Cone-Specific Filter-Based Neuromodulation: A Proposed Clinical Framework for Amblyopia, Strabismus, and ADHD.Clinics and practice · 2025Article
- S-cone-specific circuitry in the outer plexiform layer of a cone-dominant mammal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Amacrine cell inputs to OFF midget ganglion cells in macaque retina.The Journal of physiology · 2025Article
- Computational evidence for an inverse relationship between retinal and brain complexity.Journal of vision · 2025Article
- Review
- A circuit motif for color in the human foveal retina.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Unique yellow shifts for small and brief stimuli in the central retina.Journal of vision · 2024Article
- Unusual morphology of foveal Müller glia in an adult human born pre-term.Frontiers in cellular neuroscience · 2024Article
- The mechanism of human color vision and potential implanted devices for artificial color vision.Frontiers in neuroscience · 2024Review
- Investigation of heterocellular features of the mouse retinal neurovascular unit by 3D electron microscopy.Journal of anatomy · 2023Article
- Enhanced S-Cone Syndrome: Elevated Cone Counts Confer Supernormal Visual Acuity in the S-Cone Pathway.Investigative ophthalmology & visual science · 2023Article
- Comparative connectomics reveals noncanonical wiring for color vision in human foveal retina.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- New insights into retinal circuits through EM connectomics: what we have learnt and what remains to be learned.Frontiers in ophthalmology · 2023Review
- Cone opponent functional domains in primary visual cortex combine signals for color appearance mechanisms.Nature communications · 2022Article
- Origins of direction selectivity in the primate retina.Nature communications · 2022Article
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Authors and funding
4 authors.
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Abstract
In the trichromatic primate retina, the "midget" retinal ganglion cell is the classical substrate for red-green color signaling, with a circuitry that enables antagonistic responses between long (L)- and medium (M)-wavelength-sensitive cone inputs. Previous physiological studies showed that some OFF midget ganglion cells may receive sparse input from short (S)-wavelength-sensitive cones, but the effect of S-cone inputs on the chromatic tuning properties of such cells has not been explored. Moreover, anatomical evidence for a synaptic pathway from S cones to OFF midget ganglion cells through OFF midget bipolar cells remains ambiguous. In this study, we address both questions for the macaque monkey retina. First, we used serial block-face electron microscopy to show that every S cone in the parafoveal retina synapses principally with a single OFF midget bipolar cell, which in turn forms a private-line connection with an OFF midget ganglion cell. Second, we used patch electrophysiology to characterize the chromatic tuning of OFF midget ganglion cells in the near peripheral retina that receive combined input from L, M, and S cones. These "S-OFF" midget cells have a characteristic S-cone spatial signature, but demonstrate heterogeneous color properties due to the variable strength of L, M, and S cone input across the receptive field. Together, these findings strongly support the hypothesis that the OFF midget pathway is the major conduit for S-OFF signals in primate retina and redefines the pathway as a chromatically complex substrate that encodes color signals beyond the classically recognized L versus M and S versus L+M cardinal mechanisms.
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