Evidence map›Paper›PMID 31405887›Full record

ArticlePediatrics2019

Racial and Ethnic Differences Over Time in Outcomes of Infants Born Less Than 30 Weeks' Gestation.

Nansi S Boghossian, Marco Geraci, Scott A Lorch, Ciaran S Phibbs, Erika M Edwards, Jeffrey D Horbar

Registry-linked trialAbstract readMulticenter Study
In one paragraph

Article in Pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05328817 (Azithromycin Versus Erythromycin For Preterm Prelabor Rupture of Membranes), which is not on this map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05328817 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Azithromycin Versus Erythromycin For Preterm Prelabor Rupture of Membranes: A Randomized Controlled Trial

TypeinterventionalSponsorEastern Virginia Medical SchoolRan2022 to 2025Enrolled240ConditionsPreterm Premature Rupture of MembraneArmsAntibiotics
3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

  1. Article
  2. Differential transport patterns by race and ethnicity in very low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  3. Article
  4. Diversity, equity, and inclusion considerations for anti-racist, equity-focused NICU family mental health.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
  5. Article
  6. Continuum of care for patients through medical-legal partnership: improving the transition from NICU stay to home.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
  7. Racial and ethnic disparities in postnatal growth of infants born before 30 weeks of gestation.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Neonatal respiratory care practice among level III and IV NICUs in New England.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  18. Persistent disparities in black infant mortality across gestational ages in the United States.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Nansi S BoghossianDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina; nboghoss@mailbox.sc.edu.
Marco GeraciDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.
Scott A LorchDivision of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Ciaran S PhibbsHealth Economics Resource Center and Center for Implementation to Innovation, Veterans Affairs Palo Alto Health Care System, Menlo Park, California.
Erika M EdwardsVermont Oxford Network, Burlington, Vermont.
Jeffrey D HorbarVermont Oxford Network, Burlington, Vermont.

Funding

A Dashboard of Racial/Ethnic Disparity in Care Provided by NICUsR01HD083368 · NICHD · STANFORD UNIVERSITY · PI PROFIT, JOCHEN · 2016 to 2020
$3.2M
Racial/ethnic disparities in care practices, outcomes, and hospital transfer among infants born at 22-29 weeks gestationR03HD097305 · NICHD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BOGHOSSIAN, NANSI · 2019 to 2020
$149k
NICHD NIH HHS R01 HD083368NICHD NIH HHS R03 HD097305
6 · The paper itself

Abstract

objectivesTo examine changes in care practices over time by race and ethnicity and whether the decrease in hospital mortality and severe morbidities has benefited infants of minority over infants of white mothers.

methodsInfants 22 to 29 weeks' gestation born between January 2006 and December 2017 at a Vermont Oxford Network center in the United States were studied. We examined mortality and morbidity rate differences and 95% confidence intervals for African American and Hispanic versus white infants by birth year. We tested temporal differences in mortality and morbidity rates between white and African American or Hispanic infants using a likelihood ratio test on nested binomial regression models.

resultsDisparities for certain care practices such as antenatal corticosteroids and for some in-hospital outcomes have narrowed over time for minority infants. Compared with white infants, African American infants had a faster decline for mortality, hypothermia, necrotizing enterocolitis, and late-onset sepsis, whereas Hispanic infants had a faster decline for mortality, respiratory distress syndrome, and pneumothorax. Other morbidities showed a constant rate difference between African American and Hispanic versus white infants over time. Despite the improvements, outcomes including hypothermia, mortality, necrotizing enterocolitis, late-onset sepsis, and severe intraventricular hemorrhage remained elevated by the end of the study period, especially among African American infants.

conclusionsRacial and ethnic disparities in vital care practices and certain outcomes have decreased. That the quality deficit among minority infants occurred for several care practice measures and potentially modifiable outcomes suggests a critical role for quality improvement initiatives tailored for minority-serving hospitals.

Indexed as

Infant, Extremely PrematureMorbidityBlack or African AmericanEthnicityFemaleHealthcare DisparitiesHispanic or LatinoHumansInfantInfant MortalityIntensive Care Units, NeonatalPregnancyPregnancy ComplicationsPuerto RicoRace FactorsRetrospective Studies

Identifiers

PMID31405887
PMCPMC6813804

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.