ArticleAntimicrobial agents and chemotherapy2019
Pyrrolomycins Are Potent Natural Protonophores.
Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Broad-Spectrum Anti-Infective Activity of Natural Compounds Pyrrolomycins, Marinopyrroles, and Their Analogs.Pathogens (Basel, Switzerland) · 2026Review
- Genome-Mining Based Discovery of Pyrrolomycin K and L from the Termite-AssociatedJournal of natural products · 2025Article
- Cancer Cell Cytotoxicity of Marinopyrroles, Pyrrolomycins, and Their Derivatives.Marine drugs · 2025Review
- Expanded Gram-Negative Activity of Marinopyrrole A.Pathogens (Basel, Switzerland) · 2025Article
- Unlocking the Potential of Pyrrole: Recent Advances in New Pyrrole-Containing Compounds with Antibacterial Potential.International journal of molecular sciences · 2024Review
- Antibacterial Marinopyrroles and Pseudilins Act as Protonophores.ACS chemical biology · 2024Article
- Total Synthesis and Biological Investigation of Mindapyrroles A and B.ChemMedChem · 2023Article
- Review
- The Diverse Biological Activity of Recently Synthesized Nitro Compounds.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Total synthesis and mechanism of action of the antibiotic armeniaspirol A.Chemical science · 2021Article
- Article
- Trialkyl(vinyl)phosphonium Chlorophenol Derivatives as Potent Mitochondrial Uncouplers and Antibacterial Agents.ACS omega · 2021Article
- Membrane Depolarization Sensitizes Pseudomonas aeruginosa Against Tannic Acid.Current microbiology · 2021Article
- Brevibacillin 2V Exerts Its Bactericidal ActivityFrontiers in microbiology · 2021Article
- BrevicidineB, a New Member of the Brevicidine Family, Displays an Extended Target Specificity.Frontiers in microbiology · 2021Article
- New Synthetic Nitro-Pyrrolomycins as Promising Antibacterial and Anticancer Agents.Antibiotics (Basel, Switzerland) · 2020Article
- Fluorescein Derivatives as Antibacterial Agents Acting via Membrane Depolarization.Biomolecules · 2020Article
- Fifty Years of Research on Protonophores: Mitochondrial Uncoupling As a Basis for Therapeutic Action.Acta naturaeArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The escalating burden of antibiotic drug resistance necessitates research into novel classes of antibiotics and their mechanism of action. Pyrrolomycins are a family of potent natural product antibiotics with nanomolar activity against Gram-positive bacteria, yet with an elusive mechanism of action. In this work, we dissect the apparent Gram-positive specific activity of pyrrolomycins and show that Gram-negative bacteria are equally sensitive to pyrrolomycins when drug efflux transporters are removed and that albumin in medium plays a large role in pyrrolomycin activity. The selection of resistant mutants allowed for the characterization and validation of a number of mechanisms of resistance to pyrrolomycins in both
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.