Evidence map›Paper›PMID 31405851›Full record

ArticleAntimicrobial agents and chemotherapy2019

Extended-Interval Dosing of Rezafungin against Azole-Resistant Aspergillus fumigatus.

Nathan P Wiederhold, Laura K Najvar, Rosie Jaramillo, Marcos Olivo, Brian L Wickes, Gabriel Catano, Thomas F Patterson

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Azole-ResistantJournal of fungi (Basel, Switzerland) · 2025
    Review
  2. Invasive Aspergillosis in the Intensive Care Unit.Journal of fungi (Basel, Switzerland) · 2025
    Review
  3. Review
  4. Invasive Pulmonary Aspergillosis.Journal of fungi (Basel, Switzerland) · 2023
    Review
  5. Review
  6. Metabolism, Excretion, and Mass Balance of [Antimicrobial agents and chemotherapy · 2022
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nathan P WiederholdDepartment of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA wiederholdn@uthscsa.edu.ORCID 0000-0002-2225-5122
Laura K NajvarDepartment of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Rosie JaramilloDepartment of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Marcos OlivoDepartment of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Brian L WickesDepartment of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Gabriel CatanoDepartment of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Thomas F PattersonDepartment of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
The University of Texas Health Science Center at San Antonio · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated extended-interval dosing of the investigational echinocandin rezafungin (1, 4, and 16 mg/kg on days 1, 4, and 7 postinoculation) for the treatment of disseminated invasive aspergillosis caused by azole-resistant

Indexed as

AnimalsAntifungal AgentsAspergillosisAspergillus fumigatusAzolesDrug Resistance, FungalEchinocandinsFungal ProteinsKidneyMaleMiceReal-Time Polymerase Chain ReactionTriazolesAntifungal AgentsAzolesEchinocandinsFungal ProteinsposaconazoleRezafunginTriazolesAspergillus fumigatusazole resistanceinvasive aspergillosismurine modelrezafunginTR34/L98H

Identifiers

PMID31405851
PMCPMC6761546
OpenAlexW2964683145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.