ArticleJournal of infection and public health2020
Diagnosis of severe dengue: Challenges, needs and opportunities.
Article in Journal of infection and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Retrospective Study of Climate Change Affecting Dengue: Evidences, Challenges and Future Directions.Frontiers in public health · 2022Pooled it
- High-Throughput Virtual Screening of Phytochemicals From Indian Medicinal Plants for the Identification of Potential Inhibitors Against NS2B-NS3 Protease of Dengue Virus.Biotechnology and applied biochemistry · 2026Article
- Epidemiological, virological, and clinical characteristics of dengue in the Lao People's Democratic Republic, 2022-2023: a cross-sectional study.Tropical medicine and health · 2026Article
- Article
- Diagnostic Techniques for Dengue Virus.Current topics in microbiology and immunology · 2026Review
- Evaluation of immune-endothelial activation markers for the differentiation of severe dengue.Journal of translational medicine · 2025Article
- Risk Stratification of Dengue Cases Requiring Hospitalization.Journal of medical virology · 2025Article
- Environmental Determinants of Dengue Fever: A Re-Emerging Threat in the Middle East.Health science reports · 2025Article
- Multilayer Fluorescent Immunoassay for Early and Sensitive Dengue Virus Detection Using Host and Viral Biomarkers.Bioconjugate chemistry · 2025Article
- Article
- Addressing knowledge, attitude and practice gaps for effective dengue management strategies in Indonesia.Frontiers in public health · 2025Article
- Single-cell sequencing reveals the features of adaptive immune responses in the liver of a mouse model of dengue fever.Animal models and experimental medicine · 2025Article
- Antiviral Effect of MicroalgaeMarine drugs · 2024Article
- Using Computational Simulations Based on Fuzzy Cognitive Maps to Detect Dengue Complications.Diagnostics (Basel, Switzerland) · 2024Article
- Synthesis and biological activity of imidazole phenazine derivatives as potential inhibitors for NS2B-NS3 dengue protease.Heliyon · 2024Article
- Complete Blood Count Values Over Time in Young Children During the Dengue Virus Epidemic in the Dominican Republic From 2018 to 2020.BioMed research international · 2024Article
- Dengue as a Disease Threatening Global Health: A Narrative Review Focusing on Latin America and Brazil.Tropical medicine and infectious disease · 2023Review
- Development and Utility of Practical Indicators of Critical Outcomes in Dengue Patients Presenting to Hospital: A Retrospective Cross-Sectional Study.Tropical medicine and infectious disease · 2023Article
- Rapid Diagnostic Tests for the Detection of the Four Dengue Virus Serotypes in Clinically Relevant Matrices.Microbiology spectrum · 2023Article
- Article
Corrections and comments
- Commented on by
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDelayed diagnosis of dengue cases with increased risk for severe disease could lead to poor disease outcome. To date there is no specific laboratory diagnostic test for severe dengue. This qualitative study explored expert views regarding current issues in diagnosing severe dengue, rationale for severe dengue-specific diagnostics, future prospects and features of potential diagnostics for severe dengue.
methodsIn-depth individual interviews with thematic saturation were conducted between May and July 2018. The data was analyzed using thematic analysis.
resultsBased on expert opinion, diagnosis of severe dengue is challenging as it depends on astute clinical interpretation of non-dengue-specific clinical and laboratory findings. A specific test that detects impending manifestation of severe dengue could 1) overcome failure in identifying severe disease for referral or admission, 2) facilitate timely and appropriate management of plasma leakage and bleeding, 3) overcome the lack of clinical expertise and laboratory diagnosis in rural health settings. The most important feature of any diagnostics for severe dengue is the point-of-care (POC) format where it can be performed at or near the bedside.
conclusionThe development of diagnostics to detect impending severe dengue is warranted to reduce the morbidity and mortality rates of dengue infection and it should be prioritized.
Indexed as
Identifiers
31405788What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.