Evidence map›Paper›PMID 31405720›Full record

ArticleReproductive biomedicine online2019

Preconception serum lipids and lipophilic micronutrient levels are associated with live birth rates after IVF.

Erica L Jamro, Michael S Bloom, Richard W Browne, Keewan Kim, Eleni A Greenwood, Victor Y Fujimoto

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive biomedicine online, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Erica L JamroDepartment of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer NY 12144, USA.
Michael S BloomDepartment of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer NY 12144, USA; Department of Environmental Health Sciences, University at Albany, State University of New York, One University Place, School of Public Health, GEC #157, Rensselaer NY 12144, USA. Electronic address: mbloom@albany.edu.
Richard W BrowneDepartment of Biotechnical and Clinical Laboratory Sciences, University at Buffalo, State University of New York, Buffalo NY 14214, USA.
Keewan KimEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda MD 20892, USA.
Eleni A GreenwoodDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California at San Francisco, San Francisco CA 94158, USA.
Victor Y FujimotoDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California at San Francisco, San Francisco CA 94158, USA.
Albany State University · USUniversity of California, San Francisco · USNational Institutes of Health · USUniversity at Buffalo, State University of New York · US

Funding

High Density Lipoprotein (HDL) in Follicular Fluid and Fertility OutcomesR21AG031957 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FUJIMOTO, VICTOR YUTAKA · 2010 to 2011
$443k
NIA NIH HHS R21 AG031957
6 · The paper itself

Abstract

research questionIs a mixture of preconception serum lipids and lipophilic micronutrients associated with clinical pregnancy and live births?

designIn this prospective cohort study, blood serum was collected on the day of oocyte retrieval for 180 women undergoing IVF at an academic reproductive health centre. Concentrations of lipids (phospholipids, total cholesterol, high- and low-density lipoproteins, and triglycerides) and lipophilic micronutrients (α-, δ-, and γ-tocopherols, retinol, β- and α-carotenes, β-cryptoxanthin, lutein and lycopene) were determined using diagnostic reagent kits and high-performance liquid chromatography. Poisson regression was used with robust variance estimation to evaluate changes in Z-scores for the mixture of serum lipid and lipophilic micronutrient concentrations as predictors of embryo implantation, clinical pregnancy and live birth, adjusted for age, body mass index (BMI), race, smoking status, infertility diagnosis, ovarian stimulation protocol and other measured lipid and lipophilic micronutrient concentrations.

resultsEach SD higher serum triglyceride concentration was associated with a lower chance of live birth (RR 0.54; 95% CI 0.33 to 0.90) whereas a 1 SD higher serum α-tocopherol concentration, as part of a mixture of serum lipids and lipophilic micronutrients, was associated with a higher likelihood for a live birth (RR 1.61; 95% CI 1.11 to 2.36). Serum β-carotene concentrations were associated with live birth in a non-linear fashion; low β-carotene was associated with a lower chance of live birth and high β-carotene with a higher chance of live birth.

conclusionAlthough components of a mixture of lipids and lipophilic micronutrients were associated with live birth outcomes after IVF, a larger investigation is necessary to fully evaluate the potential clinical implications.

Indexed as

Fertilization in VitroPregnancy RateAdultCohort StudiesFemaleHumansInfant, NewbornInfertilityLipidsLive BirthMaleMicronutrientsMiddle AgedOvulation InductionPregnancyPregnancy OutcomeLipidsMicronutrientsAlpha-tocopherolIn vitro fertilization (IVF)LipidsLive birthMicronutrientsTriglycerides

Identifiers

PMID31405720
PMCPMC6779515
OpenAlexW2953268706

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.