Evidence map›Paper›PMID 31405270›Full record

ArticleClinical and experimental reproductive medicine2019

Analysis of vitamin D-binding protein (VDBP) gene polymorphisms in Korean women with and without endometriosis.

Min-Chul Cho, Jin Hyun Kim, Myeong Hee Jung, In Ae Cho, Hyen Chul Jo, Jeong Kyu Shin, Soon Ae Lee, Won Jun Choi, Jong Hak Lee

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental reproductive medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06289257 (Analysis of Vitamin D and VDR Expression in Women With Advanced Endometriosis), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06289257 completednot on this mapstarted 2024, after this paper: background citation

Analysis of Vitamin D and VDR Expression in Women With Advanced Endometriosis: A Case-Control Study in Thailand

Typeobservational_patient_registrySponsorKhon Kaen UniversityRan2024 to 2024Enrolled108ConditionsEndometriosis, Vitamin D Deficiency/Insufficiency, Vitamin D StatusArmsVitamin D level, Vitamin D receptor
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Vitamin D and Endometriosis: Is There a Mechanistic Link?Cell biochemistry and function · 2025
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  3. Article
  4. Article
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  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Min-Chul ChoDepartment of Laboratory Medicine, Gyeongsang National University Hospital and Gyeongsang National University College of Medicine, Jinju, Korea.
Jin Hyun KimInstitute of Health Sciences, Gyeongsang National University, Jinju, Korea.
Myeong Hee JungBiomedical Research Institute, Gyeongsang National University Hospital, Jinju, Korea.
In Ae ChoDepartment of Obstetrics and Gynecology, Gyeongsang National University Hospital, Jinju, Korea.
Hyen Chul JoDepartment of Obstetrics and Gynecology, Gyeongsang National University Changwon Hospital, Changwon, Korea.
Jeong Kyu ShinInstitute of Health Sciences, Gyeongsang National University, Jinju, Korea.
Soon Ae LeeInstitute of Health Sciences, Gyeongsang National University, Jinju, Korea.
Won Jun ChoiInstitute of Health Sciences, Gyeongsang National University, Jinju, Korea.
Jong Hak LeeInstitute of Health Sciences, Gyeongsang National University, Jinju, Korea.
Gyeongsang National University · KRGyeongsang National University Hospital · KRChangwon National University · KR

Funding

Gyeongsang National University Hospital GNUHBRIF-2017-0006Ministry of Science and ICTNational Research Foundation of Korea 2018R1C1B5040593
6 · The paper itself

Abstract

objectiveVitamin D-binding protein (VDBP) mediates various biological processes in humans. The goal of this study was to investigate whether VDBP gene polymorphisms could predispose Korean women to endometriosis.

methodsWe prospectively enrolled women with endometriosis (n = 16) and healthy controls (n = 16). Total serum 25-hydroxyl vitamin D (25(OH)D) concentrations were measured using an Elecsys vitamin D total kit. Levels of bioavailable and free 25(OH)D were calculated. Concentrations of VDBP were measured using a vitamin D BP Quantikine ELISA kit. DNA was extracted using a DNeasy blood & tissue kit. Two singlenucleotide polymorphisms (SNPs; rs4588 and rs7041) in GC, the gene that codes for VDBP, were analyzed using a TaqMan SNP genotyping assay kit. The functional variant of VDBP was determined based on the results of the two SNPs.

resultsGravidity and parity were significantly lower in the endometriosis patients than in the control group, but serum CA-125 levels and the erythrocyte sedimentation rate were significantly higher. Total serum 25(OH)D levels in the endometriosis patients were significantly lower than in the control group. However, serum bioavailable 25(OH)D, free 25(OH)D, and VDBP levels did not differ significantly between the endometriosis and control groups. The genotypes and allele frequencies of GC were similar in both groups.

conclusionKorean women with endometriosis had lower total serum 25(OH)D concentrations than controls. Neither serum VDBP concentrations nor polymorphisms in the gene coding for VDBP were associated with endometriosis. Further studies are needed to investigate the pathophysiology and clinical implications of 25(OH)D and VDBP in endometriosis.

Indexed as

EndometriosisGenetic polymorphismVitamin DVitamin D-binding protein

Identifiers

PMID31405270
PMCPMC6736509
OpenAlexW2967589558

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.