Evidence map›Paper›PMID 31405159›Full record

ArticlePharmaceutics2019

Factorial Design as a Tool for the Optimization of PLGA Nanoparticles for the Co-Delivery of Temozolomide and O6-Benzylguanine.

Maria João Ramalho, Joana A Loureiro, Manuel A N Coelho, Maria Carmo Pereira

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maria João RamalhoLEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.ORCID 0000-0003-2428-7520
Joana A LoureiroLEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.
Manuel A N CoelhoLEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.
Maria Carmo PereiraLEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal. mcsp@fe.up.pt.

Funding

Characterization of C-1027 Enediyne Polyketide SynthaseF32CA105984 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI VAN LANEN, STEVEN GARY · 2004 to 2006
$134k
European Regional Development Fund LEPABE-2-ECO-INNOVATION" - NORTE-01-0145-FEDER-000005European Regional Development Fund POCI-01-0145-FEDER-006939Fundação para a Ciência e a Tecnologia PD/BD/105984/2014Fundação para a Ciência e a Tecnologia UID/EQU/00511/2019
6 · The paper itself

Abstract

Poly(d,l-lactic-

Indexed as

drug deliveryexperimental designfractional factorial designglioblastoma multiformeO6-methylguanine DNA methyltransferase (MGMT) protein

Identifiers

PMID31405159
PMCPMC6722980

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.