ArticleJournal of clinical medicine2019
Modeling the Longitudinal Effects of Insight on Depression, Quality of Life and Suicidality in Schizophrenia Spectrum Disorders: Results from the FACE-SZ Cohort.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Confidence in visual motion discrimination is preserved in individuals with schizophrenia.Journal of psychiatry & neuroscience : JPN · 2021Trial
- Changes in insight and outcome over the early course of first-episode psychosis. The OPTiMiSE trial.Schizophrenia research. Cognition · 2026Article
- Predictors for quality of life improvement in schizophrenia: a prospective study of patients in hospital-based rehabilitation programs.BMC psychiatry · 2026Article
- Establishment and characterization of TK-DDCS1: a novel IDH1 mutated dedifferentiated chondrosarcoma cell line.Human cell · 2025Article
- Establishment and characterization of a novel dedifferentiated chondrosarcoma cell line, SMU-DDCS, harboring an IDH1 mutation.Human cell · 2023Article
- [Suicidality in schizophrenic psychosis: a current overview].Der Nervenarzt · 2021Review
- Outcome prediction with a social cognitive battery: a multicenter longitudinal study.NPJ schizophrenia · 2021Article
- Self-Harm History, Anxiety-Depression, Severity of Disease, and Insight Are Significantly Associated With Suicide Risk in Forensic Psychiatric Inpatients of China.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
23 authors.
Funding
Abstract
backgroundUp to half of the patients with schizophrenia attempt suicide during their lifetime. Better insight is associated with better functioning but also with increased suicidality. The direction of the relationship between insight and suicidality is not clear, hence we aimed to provide new elements using structural equation modeling.
methodsInsight, quality of life (QoL), depression, and suicidality were measured at baseline and at 12 months in individuals with schizophrenia spectrum disorders. The relationships between these variables were investigated by latent difference score models, controlling for chlorpromazine doses, positive and negative symptoms, and general psychopathology.
results738 patients were included, and 370 completed the study. Baseline levels of insight predicted changes in suicidality, whereas baseline levels of suicidality did not predict changes in insight, suggesting that better insight underlies suicidality and predicts its worsening. Our results suggest this temporal sequence: better insight → worse QoL → increased depression → increased suicidality, while insight also affects the three variables in parallel.
conclusionBetter insight predicts a worsening of QoL, depression and suicidality. These findings contribute to our global understanding of the longitudinal influence of insight on suicidality. We advocate that insight-targeted interventions should not be proposed without the monitoring of depression and suicide prevention.
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