ArticleNanomaterials (Basel, Switzerland)2019
Ionic Liquid-Polymer Nanoparticle Hybrid Systems as New Tools to Deliver Poorly Soluble Drugs.
Article in Nanomaterials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Injectable Self-Healing Fucoidan-Chitosan Hydrogel Incorporating Polydopamine-Silver-Rutin Nanoparticles for Multifunctional Wound Dressing.Molecules (Basel, Switzerland) · 2026Article
- Ionic Liquid-Enabled Drug Delivery Systems: Benefits, Limitations, and Future Perspectives.Pharmaceutics · 2026Review
- Beyond the Solvent: Engineering Ionic Liquids for Biomedical Applications-Advances, Challenges, and Future Directions.Molecules (Basel, Switzerland) · 2026Review
- Fagonia indica extract encapsulated in PLGA nanocarriers demonstrated enhanced therapeutic efficacy through improved intracellular uptake of photoactive metabolites.Scientific reports · 2025Article
- Anticancer Effects of MAPK6 siRNA-Loaded PLGA Nanoparticles in the Treatment of Breast Cancer.Journal of cellular and molecular medicine · 2025Article
- Percutaneous Delivery of Oncogel for Targeted Liver Tumor Ablation and Controlled Release of Therapeutics.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Hyaluronic Acid-Based Nanoparticles Loaded with Rutin as Vasculo-Protective Tools against Anthracycline-Induced Endothelial Damages.Pharmaceutics · 2024Article
- Ionic Liquids in Pharmaceutical and Biomedical Applications: A Review.Pharmaceutics · 2024Review
- Characterization and Preliminary In Vitro Antioxidant Activity of a New Multidrug Formulation Based on the Co-Encapsulation of Rutin and the α-Acylamino-β-Lactone NAAA Inhibitor URB894 within PLGA Nanoparticles.Antioxidants (Basel, Switzerland) · 2023Article
- Application of High Potential Electrophoretic Particles Modified with High Ionization Mono Ionic Liquid for Electrophoretic Displays.Micromachines · 2022Article
- A Novel Modification of Copper (II) Phthalocyanine Particles towards Electrophoretic Displays.Micromachines · 2022Article
- Enhanced Anticancer Activity ofPharmaceuticals (Basel, Switzerland) · 2022Article
- Oxygen and Drug-Carrying Periodic Mesoporous Organosilicas for Enhanced Cell Viability under Normoxic and Hypoxic Conditions.International journal of molecular sciences · 2022Article
- 3D-Printable Oxygen- and Drug-Carrying Nanocomposite Hydrogels for Enhanced Cell Viability.Nanomaterials (Basel, Switzerland) · 2022Article
- TransfersomILs: From Ionic Liquids to a New Class of Nanovesicular Systems.Nanomaterials (Basel, Switzerland) · 2021Article
- Gelatin hydrogel/contact lens composites as rutin delivery systems for promoting corneal wound healing.Drug delivery · 2021Article
- Ionic Liquid-Based Materials for Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2021Review
- Biobased Ionic Liquids as Multitalented Materials in Lipidic Drug Implants.Pharmaceutics · 2021Article
- Upgrading the Topical Delivery of Poorly Soluble Drugs Using Ionic Liquids as a Versatile Tool.International journal of molecular sciences · 2021Article
- Crucial Role of PLGA Nanoparticles in Mitigating the Amiodarone-Induced Pulmonary Toxicity.International journal of nanomedicine · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The use of functional excipients such as ionic liquids (ILs) and the encapsulation of drugs into nanocarriers are useful strategies to overcome poor drug solubility. The aim of this work was to evaluate the potential of IL-polymer nanoparticle hybrid systems as tools to deliver poorly soluble drugs. These systems were obtained using a methodology previously developed by our group and improved herein to produce IL-polymer nanoparticle hybrid systems. Two different choline-based ILs and poly (lactic-co-glycolic acid) (PLGA) 50:50 or PLGA 75:25 were used to load rutin into the delivery system. The resulting rutin-loaded IL-polymer nanoparticle hybrid systems presented a diameter of 250-300 nm, with a low polydispersity index and a zeta potential of about -40 mV. The drug association efficiency ranged from 51% to 76%, which represents a good achievement considering the poor solubility of rutin. No significant particle aggregation was obtained upon freeze-drying. The presence of the IL in the nanosystem does not affect its sustained release properties, achieving about 85% of rutin released after 72 h. The cytotoxicity studies showed that the delivery system was not toxic to HaCat cells. Our findings may open a new paradigm on the therapy improvement of diseases treated with poorly soluble drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.