ReviewNutrients2019
The Role of Water Homeostasis in Muscle Function and Frailty: A Review.
Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
107 citing papers in PubMed, 227 citations in OpenAlex.
- Bioelectrical Impedance in Monitoring Hyperhydration and Muscle Wasting in Critically Ill Corona Virus Disease (COVID-19) Patients: The Feasibility of Predicting Outcome.Physiological research · 2025Trial
- The Efficacy and Safety of Canagliflozin by Frailty Status in Participants of the CANVAS and CREDENCE Trials.Journal of the American Geriatrics Society · 2025Trial
- The Effect of Acute Dehydration upon Muscle Strength Indices at Elite Karate Athletes: A Randomized Crossover Study.Nutrients · 2025Trial
- Antiobesity and Hypolipidemic Potential ofNutrients · 2024Trial
- Dynamic Adjustments of Parenteral Support in Early Adult Intestinal Failure-Essential Role of Sodium.Nutrients · 2020Trial
- Mechanisms Influencing Maximum Joint Range of Motion and Stiffness: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2026Review
- Hepatic SIRT6 Deficiency Accelerates Female-Specific Aging Through SULT1E1-Mediated Estrogen Depletion.International journal of molecular sciences · 2026Article
- Enhanced Quantitative Phosphocreatine MR Imaging of Skeletal Muscle Using a Global-Local Two-Branch Deep Learning Model.Magnetic resonance in medicine · 2026Article
- Effects of dietary starch-to-lipid ratios and amino acid levels on broilers exposed to cyclic heat stress during the finisher period.Poultry science · 2026Article
- Nutritional and Performance Effects of Partial Replacement of Maize With Cassava Root (Food science & nutrition · 2026Article
- Extracellular water may increase with age and be independently and negatively associated with muscle strength and physical function in older adults: A cross-sectional study.Physiological reports · 2026Article
- Climate Change and Sarcopenia: Mechanisms, Vulnerabilities, and Public Health Implications.Calcified tissue international · 2026Review
- Advancing sarcopenia assessment with wearable and app-based technology: a scoping review.The journal of nutrition, health & aging · 2026Article
- Water Molecule(s) Inside the Selectivity Filter of Aquaporin 1: A DFT Study.Molecules (Basel, Switzerland) · 2026Article
- NRS2002-stratified body composition and laboratory characteristics in hospitalized cancer patients assessed by bioelectrical impedance analysis.Frontiers in nutrition · 2026Article
- Dietary and body composition profiles in Chinese pediatric late-onset Pompe disease: implications for nutritional management.Frontiers in medicine · 2026Article
- Artificial Intelligence-Derived 3D Body Composition Analysis of the Entire Lumbar Region From CT Scans Reveals Variation Across Disease Stages at Colorectal Cancer Diagnosis.Radiology research and practice · 2026Article
- Time-Dependent Changes in Extracellular-to-Intracellular Water Ratios and Risk of All-Cause Mortality in Peritoneal Dialysis Patients: A Single-Center Retrospective Cohort Study.Kidney medicine · 2026Article
- Neuromuscular Electrical Stimulation Plus Nutritional Counseling Attenuates Thigh Muscle Thickness Loss in Hospitalized Cancer Patients.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Article
- Insulin Deficiency Exacerbates Muscle Atrophy and Osteopenia inInternational journal of molecular sciences · 2025Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Water, the main component of the body, is distributed in the extracellular and intracellular compartments. Water exchange between these compartments is mainly governed by osmotic pressure. Extracellular water osmolarity must remain within very narrow limits to be compatible with life. Older adults lose the thirst sensation and the ability to concentrate urine, and this favours increased extracellular osmolarity (hyperosmotic stress). This situation, in turn, leads to cell dehydration, which has severe consequences for the intracellular protein structure and function and, ultimately, results in cell damage. Moreover, the fact that water determines cell volume may act as a metabolic signal, with cell swelling acting as an anabolic signal and cell shrinkage acting as a catabolic signal. Ageing also leads to a progressive loss in muscle mass and strength. Muscle strength is the main determinant of functional capacity, and, in elderly people, depends more on muscle quality than on muscle quantity (or muscle mass). Intracellular water content in lean mass has been related to muscle strength, functional capacity, and frailty risk, and has been proposed as an indicator of muscle quality and cell hydration. This review aims to assess the role of hyperosmotic stress and cell dehydration on muscle function and frailty.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.