Evidence map›Paper›PMID 31405055›Full record

ArticlePharmacy (Basel, Switzerland)2019

A Cross-Sectional Investigation for Verification of Globalization of Falsified Medicines in Cambodia, Indicated by Tablets of Sildenafil Citrate.

Naoko Yoshida, Miku Yuasa, Tey Sovannarith, Eav Dararth, Tep Keila, Heng Bun Kiet, Hirohito Tsuboi, Tsuyoshi Tanimoto, Kazuko Kimura

Open access · goldAbstract read
In one paragraph

Article in Pharmacy (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Substandard and Falsified Medicines in Myanmar.Pharmacy (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Naoko YoshidaClinical Pharmacy and Healthcare Science, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-Machi, Kanazawa 920-1192, Japan. naoko@p.kanazawa-u.ac.jp.
Miku YuasaClinical Pharmacy and Healthcare Science, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-Machi, Kanazawa 920-1192, Japan.
Tey SovannarithNational Health Product Quality Control Center, Ministry of Health, 151-153 Kampuchea Krom St., Khan 7 Makara, Phnom Penh 12250, Cambodia.
Eav DararthDepartment of Drugs and Food, Ministry of Health, 151-153 Kampuchea Krom St., Khan 7 Makara 12250, Phnom Penh, Cambodia.
Tep KeilaNational Health Product Quality Control Center, Ministry of Health, 151-153 Kampuchea Krom St., Khan 7 Makara, Phnom Penh 12250, Cambodia.
Heng Bun KietDepartment of Drugs and Food, Ministry of Health, 151-153 Kampuchea Krom St., Khan 7 Makara 12250, Phnom Penh, Cambodia.
Hirohito TsuboiClinical Pharmacy and Healthcare Science, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-Machi, Kanazawa 920-1192, Japan.
Tsuyoshi TanimotoOsaka Office, Pharmaceutical and Medical Device Regulatory Science Society of Japan, Sawanotsuru building 8th Floor, 2-1-2 Hiranocho, Chuo-Ku, Osaka 541-0046, Japan.
Kazuko KimuraMedi-Quality Security Institute, Graduate School of Medical Sciences, Kanazawa University, Kakuma-Machi, Kanazawa 920-1192, Japan.
Kanazawa University · JPMinistry of Health · KH

Funding

Japan Society for the Promotion of Science KAKENHI 22406005
6 · The paper itself

Abstract

Medicine falsification is a global issue. Viagra, an erectile dysfunction therapeutic (EDT) medicine consisting primarily of sildenafil citrate, is the most commonly falsified medicine worldwide. Recently falsified EDTs have been reported multiple times in developing countries. The globalization of falsified EDTs has become a concern. In the present study, we selected sildenafil citrate tablets as an indicator and examined samples from a developing country, Cambodia, to investigate the availability of falsified sildenafil tablets in Cambodia and verify the current globalization status of falsified medicines from the standpoint of a developing country. Six samples of the originator Viagra, and 68 samples of generic sildenafil products were purchased from private drug outlets and wholesalers in Phnom Penh, Svay Rieng, and Battambang. The samples' manufacturers were contacted to authenticate the samples. The quantities and dissolution rates of active ingredients were measured by a high-performance liquid chromatography system with photodiode array. Five generic samples were strongly suspected to be falsified medicines because of their extremely low quality; however, there was little distribution and no falsified medicine alleged to be produced by the originator of Viagra, which charges high prices. That finding indicates that falsification reflects local economic circumstances.

Indexed as

falsified medicinesglobalizationsildenafil citrate

Identifiers

PMID31405055
PMCPMC6789723
OpenAlexW2968117248

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.