Evidence map›Paper›PMID 31405034›Full record

ArticleInternational journal of molecular sciences2019

High and Low Molecular Weight Hyaluronic Acid Differentially Influences Oxylipins Synthesis in Course of Neuroinflammation.

Dmitry V Chistyakov, Alina A Astakhova, Nadezda V Azbukina, Sergei V Goriainov, Viktor V Chistyakov, Marina G Sergeeva

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Dmitry V ChistyakovBelozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow 119992, Russia. chistyakof@gmail.com.ORCID 0000-0003-0137-8585
Alina A AstakhovaBelozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow 119992, Russia.
Nadezda V AzbukinaFaculty of Bioengineering and Bioinformatics, Moscow Lomonosov State University, Moscow 119234 Russia.
Sergei V GoriainovSREC PFUR Peoples' Friendship University of Russia (RUDN University), Moscow 117198, Russia.
Viktor V ChistyakovSREC PFUR Peoples' Friendship University of Russia (RUDN University), Moscow 117198, Russia.
Marina G SergeevaBelozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow 119992, Russia.
Lomonosov Moscow State University · RUPeoples' Friendship University of Russia · RU

Funding

Russian Foundation for Basic Research 18-34-20100Russian Science Foundation 18-74-00069
6 · The paper itself

Abstract

Hyaluronic acid (HA), a major glycosaminoglycan of the extracellular matrix, has cell signaling functions that are dependent on its molecular weight. Anti-inflammatory effects for high-molecular-weight (HMW) HA and pro-inflammatory effects for low-molecular-weight (LMW) HA effects were found for various myeloid cells, including microglia. Astrocytes are cells of ectodermal origin that play a pivotal role in brain inflammation, but the link between HA with different molecular weights and an inflammatory response in these cells is not clear. We tested the effects of LMW and HMW HA in rat primary astrocytes, stimulated with Poly:IC (PIC, TLR3 agonist) and lipopolysaccharide (LPS, TLR4 agonist). Oxylipin profiles were measured by the UPLC-MS/MS analysis and metabolites HDoHEs (from docosahexaenoic acid), -HETEs, prostaglandins (from arachidonic acid), DiHOMEs and HODEs (from linoleic acid) were detected. Both, HMW and LMW HA downregulated the cyclooxygenase-mediated polyunsaturated fatty acids metabolism, LMW also reduced lipoxygenase-mediated fatty acid metabolism. Taken together, the data show that both LMW and HMW (i) influence themselves on cytokines (TNFα, IL-6, IL-10), enzymes iNOS, COX-2, and oxylipin levels in extracellular medium of cultured astrocytes, (ii) induced cellular adaptations in long-term applications, (iii) modulate TLR4- and TLR3-signaling pathways. The effects of HMW and LMW HA are predominantly revealed in TLR4- and TLR3- mediated responses, respectively.

Indexed as

AnimalsAstrocytesCells, CulturedCyclooxygenase 2FemaleHyaluronic AcidInflammationInterleukin-10LipopolysaccharidesMaleMolecular WeightOxylipinsRatsRats, WistarToll-Like ReceptorsCyclooxygenase 2Hyaluronic AcidInterleukin-10LipopolysaccharidesOxylipinsToll-Like Receptorsastrocytescyclooxygenase (COX-2)eicosanoidshyaluronic acidinterleukin 10 (IL-10)neuroinflammationoxylipinstoll-like receptors (TLRs)

Identifiers

PMID31405034
PMCPMC6719050
OpenAlexW2967621635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.