Evidence map›Paper›PMID 31405022›Full record

ArticleBiomolecules2019

KDR (VEGFR2) Genetic Variants and Serum Levels in Patients with Rheumatoid Arthritis.

Agnieszka Paradowska-Gorycka, Barbara Stypinska, Andrzej Pawlik, Damian Malinowski, Katarzyna Romanowska-Prochnicka, Malgorzata Manczak, Marzena Olesinska

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

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  8. The Role of Global and Local Ancestry on Clopidogrel Response in African Americans.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Agnieszka Paradowska-GoryckaDepartment of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Spartańska 1, 02-637 Warsaw, Poland. agnieszka.paradowska-gorycka@spartanska.pl.
Barbara StypinskaDepartment of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Spartańska 1, 02-637 Warsaw, Poland.
Andrzej PawlikDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Damian MalinowskiDepartment of Pharmacology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Katarzyna Romanowska-ProchnickaDepartment of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, 02-637 Warsaw, Poland.
Malgorzata ManczakDepartment of Gerontology and Health Promotion, National Institute of Geriatrics, Rheumatology and Rehabilitation, 02-637 Warsaw, Poland.
Marzena OlesinskaDepartment of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, 02-637 Warsaw, Poland.
National Institute of Geriatrics, Rheumatology and Rehabilitation · PLPomeranian Medical University · PLMedical University of Warsaw · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated kinase insert domain-containing receptor (KDR) polymorphisms and protein levels in relation to susceptibility to and severity of Rheumatoid Arthritis (RA). 641 RA patients and 340 controls (HC) were examined for the rs1870377 KDR variant by the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) method and for rs2305948 and rs2071559 KDR single nucleotide polymorphisms (SNPs) by TaqMan SNP genotyping assay. KDR serum levels were determined by enzyme-linked immunosorbent assay (ELISA). The rs1870377 KDR variant has shown association with RA under the codominant (

Indexed as

AdolescentAdultAgedAged, 80 and overArthritis, RheumatoidFemaleGenetic VariationHumansMaleMiddle AgedPolymorphism, Single NucleotideVascular Endothelial Growth Factor Receptor-2Young AdultKDR protein, humanVascular Endothelial Growth Factor Receptor-2angiogenesisgene polymorphismsinflammationKDRprotein levelrheumatoid arthritis

Identifiers

PMID31405022
PMCPMC6727087
OpenAlexW2968822740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.