ArticleInternational journal of molecular sciences2019
Sponges of Carboxymethyl Chitosan Grafted with Collagen Peptides for Wound Healing.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Collagen from Marine Sources and Skin Wound Healing in Animal Experimental Studies: a Systematic Review.Marine biotechnology (New York, N.Y.) · 2021Pooled it
- Current Insights and Future Directions in Scar Management and Skin Regeneration.International journal of molecular sciences · 2025Review
- Anthocyanin-Dyed Cotton Enhanced with Lavender Oil Microcapsules: A Dual Approach for Color Stability and Sustained Fragrance Release.ACS omega · 2025Article
- AMPEC4:Molecules (Basel, Switzerland) · 2025Article
- Sargassum glaucescens Extract/Marine-Derived Collagen Blend Sponge and Their Properties for Wound Healing.Marine biotechnology (New York, N.Y.) · 2025Article
- Research Progress on Extracellular Matrix-Based Composite Materials in Antibacterial Field.Biomaterials research · 2025Review
- Combined Pulsed Magnetic Field and Radiofrequency Electromagnetic Field Enhances MMP-9, Collagen-4, VEGF Synthesis to Improve Wound Healing Via Hif-1α/eNOS Pathway.Aesthetic plastic surgery · 2023Article
- Preparation of Enzyme-Soluble Swim Bladder Collagen from Sea Eel (Marine drugs · 2023Article
- Progress in Research of Chitosan Chemical Modification Technologies and Their Applications.Marine drugs · 2022Review
- Injectable multifunctional CMC/HA-DA hydrogel for repairing skin injury.Materials today. Bio · 2022Article
- Fabrication and functionalization of biocompatible carboxymethyl chitosan/gelatin membranesRSC advances · 2022Article
- Improving Polysaccharide-Based Chitin/Chitosan-Aerogel Materials by Learning from Genetics and Molecular Biology.Materials (Basel, Switzerland) · 2022Review
- Conductive Adhesive and Antibacterial Zwitterionic Hydrogel Dressing for Therapy of Full-Thickness Skin Wounds.Frontiers in bioengineering and biotechnology · 2022Article
- Bioaerogels: Promising Nanostructured Materials in Fluid Management, Healing and Regeneration of Wounds.Molecules (Basel, Switzerland) · 2021Review
- Analysis of the Curative Effect and Influencing Factors of Collagen Sponge Combined with Autologous Skin Graft in the Treatment of Deep Burn Patients.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Therapeutic candidates for keloid scars identified by qualitative review of scratch assay research for wound healing.PloS one · 2021Review
- Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications-A Review.Polymers · 2020Review
- Hybrid Freeze-Dried Dressings Composed of Epidermal Growth Factor and Recombinant Human-Like Collagen Enhance Cutaneous Wound Healing in Rats.Frontiers in bioengineering and biotechnology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Burns are physically debilitating and potentially fatal injuries. Two marine biomaterials, carboxymethyl chitosan (CMC) and collagen peptides (COP), have emerged as promising burn dressings. In this paper, sponges of carboxymethyl chitosan grafted with collagen peptide (CMC-COP) were prepared by covalent coupling and freeze drying. Scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy were then used to characterize the prepared sponges. To evaluate the wound healing activity of the CMC-COP sponges, in vitro tests including cell viability scratch wound healing and scald wound healing experiments were performed in rabbits. Appearance studies revealed the porous nature of sponges and FTIR spectroscopy demonstrated the successful incorporation of COP into CMC. The in vitro scratch assay showed that treatment with CMC-COP sponges (at 100 μg/mL) had significant effects on scratch closure. For burn wounds treated with CMC-COP, regeneration of the epidermis and collagen fiber deposition was observed on day 7, with complete healing of the epidermis and wound on days 14 and 21, respectively. Based on the pathological examination by hematoxylin and eosinstaining, the CMC-COP group demonstrated pronounced wound healing efficiencies. These results confirmed that the CMC-COP treatment enhanced cell migration and promoted skin regeneration, thereby highlighting the potential application of these sponges in burn care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.